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Protein A Resins Market Size By Application (Immunoprecipitation, Antibody Purification), By Product (Natural Protein A, Recombinant Protein A), By Matrix Type (Agarose-based Matrix, Glass or Silica Gel-based Matrix, Organic Polymer-based Matrix), By End-use (Biopharmaceutical Companies, Clinical Research Laboratories, Academic Research Institutes, Contract Research Organizations), Industry Analysis Report, Regional Outlook, Application Potential, Competitive Market Share & Forecast, 2020 - 2026

  • Report ID: GMI1146
  • Published Date: Feb 2020
  • Report Format: PDF

Protein A Resins Market Size

Protein A Resins Market size exceeded USD 600 million in 2019 and is set to grow at around 8.9% CAGR between 2020 and 2026.

Protein A Resins Market

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Protein A resin chromatography is used to prepare large amount of pure materials to analyse trace of contaminates in the product. Chromatography has been used as an alternative in recent years to improve the productivity of resin capacity of chromatography purification process. Due to high specificity and affinity of protein A resins, 99 percent purity can be achieved in most generic form. Thus, aforementioned factors will poise the market growth during the given analysis time.

Protein A Resins Market Trends

Growing investment in synthetic biology and increasing focus on drug development by biotechnology and pharmaceutical companies will propel the industry growth. Biopharmaceutical industry are extensively using protein engineered products in their research activities to develop broad range of protein-based drugs. Therefore, rising use of chromatography in drug discovery and research industry will propel the market growth over the forecasted time period. 

Increasing demand of monoclonal antibodies (mAb) globally for the better treatment of chronic diseases and increasing number of pharmaceutical and biotechnology companies will boost the overall protein A resins industry growth. With better treatment options with the help of immunotherapy, the adoption will also surge. However, high cost associated with product may hinder market opportunities during the analysis timeframe.

Protein A Resins Market Analysis

Protein A Resins Market, By Application

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The application segment is bifurcated into immunoprecipitation and antibody purification. Antibody purification    includes specific isolation and specific enrichment of antibodies from polyclonal antibodies, ascites fluid and cell culture supernatant of monoclonal antibodies. Rising demand for monoclonal antibodies has triggered the commercial production and purification of mAb using protein A resins.

Antibody purification market held over USD 469 million market size in 2019. The importance of antibody purification is continuously growing owing to achievement of excellent grade purity of antibodies. In addition, wide use of chromatography, technological advancements and practical uses of antibody purification will increase its preference over others. Moreover, increasing demand of drug development will spur the market growth in the forthcoming years.

In terms of product segment, the report covers natural and recombinant resins. Recombinant protein A resins market reported more than 9% CAGR during the forecast period. Recombinant proteins are used to prepare nanoparticles for protein drug carrier. Thus, with expanding innovation in drug discovery, the market demand will increase through 2026.

Recombinant protein A is mainly used to improve solubility and to normalise sensitivity of alkaline solutions. With expanding pharmaceuticals industry and increasing technological advancements in novel drug development, the segment will proceed at significant rate.

Agarose-based matrix type accounted for over USD 499 million revenue in 2019. It is gaining massive popularity and will continue to show growth due to wide use in pharmaceutical and biotechnology industry. Owing to its high gelling strength at low concentrations, anti-convection medium for gel electrophoresis, suitable pH range and superior mechanical strength, this segment will witness positive growth.

As per the study analysis, end-use segment of protein A resins market is categorized as biopharmaceutical companies, clinical research laboratories, academic research institutes and contract research organizations. Biopharmaceutical companies segment accounted for over USD 453 million revenue size in 2019.

Due to rising prevalence of various chronic diseases and increasing demand of better treatment methods, biopharmaceutical industry will foresee high demand for protein A resins. Increasing demand for protein engineering with various advancements will further boost segmental growth. Growing application in chromatography in biopharmaceutical industry will also provide substantial segment growth.

North America Protein A Resins Market By Country

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Regionally, North America held substantial revenue share in 2019 and will witness around 9% CAGR during the analysis period. Regional growth is mainly attributed to presence of major market players constantly investing into research and development activities. Furthermore, rising prevalence of autoimmune and orphan diseases and increasing demand of better treatment methods will boost the regional market growth in the region.

Presence of major industry players in the U.S. and increasing incidence of chronic diseases will favor the U.S. protein A resins market growth. Moreover, growing demand of technologically advanced products in this country will highly impact the market growth. Furthermore, increasing drug delivery and development will offer positive market growth in the country.

Protein A Resins Market Share

Some of the eminent business players operating in the protein A resins market share include

  • GE Healthcare
  • Thermo Fisher Scientific
  • EMD Millipore
  • Bio-Rad Laboratories 

Prominent market players are adopting various organic and inorganic growth strategies to gain market share and sustain market competition.


Some of the recent industry developments:

  • In May 2016, JHL Biotech (JHL) opened biopharmaceutical manufacturing facility with single use bioprocessing technology in China. The company will use KUBio manufacturing solution delivered by GE Healthcare to produce monoclonal antibodies (mAbs) and biosimilars for commercial supply and late–stage clinical trials.
  • In November 2014, Agarose Bead Technologies (TBT) introduced PROTEIN A Agarose Resin 4 RAPID RUN product, thereby expanding company’s product portfolio.

The protein A resins industry research report includes an in-depth coverage of the industry with estimates & forecast in terms of revenue in USD from 2015 to 2026, for the following segments:

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Market Growth By Application

  • Immunoprecipitation
  • Antibody Purification

Market Outlook By Product

  • Natural protein A
  • Recombinant protein A

By matrix type

  • Agarose-based matrix
  • Glass or Silica gel-based matrix
  • Organic Polymer-based matrix

By end-use

  • Biopharmaceutical Companies
  • Clinical Research Laboratories
  • Academic Research Institutes
  • Contract Research Organizations

The above information is provided for the following regions and countries:

  • North America
    • U.S.
    • Canada
  • Europe
    • Germany
    • UK
    • France
    • Italy
    • Spain
    • Russia
  • Asia Pacific
    • Japan
    • China
    • India
    • Australia
  • Latin America
    • Brazil
    • Mexico
    • Argentina
  • Middle East & Africa
    • South Africa
    • UAE
    • Saudi Arabia
    • Qatar
    • Kuwait
    • Egypt


Authors: Mariam Faizullabhoy, Gauri Wani

Frequently Asked Questions (FAQ) :

The market size of protein A resins exceeded USD 600 million in 2019.

The industry share of protein A resins is predicted to grow at 8.9% CAGR during 2020-2026.

According to GMI report, the North America protein A resins will witness around 9% CAGR during 2020-2026.

Increasing usage of protein A resins in antibody purification procedure along with rising adoption of chromatographic techniques for identification of biochemicals will positively impact industry demand.

The biopharmaceutical companies segment accounted for over USD 453 million market size in 2019, says a GMI report.

Some of the major companies in protein A resins industry include GE Healthcare, Thermo Fisher Scientific, EMD Millipore, and Bio-Rad Laboratories, etc.

Protein A Resins Market Scope

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Premium Report Details

  • Base Year: 2019
  • Companies covered: 10
  • Tables & Figures: 265
  • Countries covered: 21
  • Pages: 131
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