Authors:
Monali Tayade, Sampada Kulkarni
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Liquid Biopsy Market Size & Share 2026-2035
Report ID: GMI3775
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Published Date: July 2026
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Liquid Biopsy Market
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Liquid Biopsy Market Size
The global liquid biopsy market was valued at USD 6.3 billion in 2025 and is projected to grow from USD 7.1 billion in 2026 to USD 19.9 billion by 2035, expanding at a CAGR of 12.1%, according to the latest report published by Global Market Insights Inc. This substantial growth is driven by several key factors, including continuous technological advancements in cancer diagnostics, increasing preference for non-invasive disease diagnosis and growing prevalence of cancer worldwide.
Liquid Biopsy Market Key Takeaways
Market Leader: Guardant Health led with over 18% market share in 2025.
Leading Players: Top 5 players in this market include Guardant Health, Thermo Fisher Scientific, Illumina, F. Hoffmann-La Roche, QIAGEN, which collectively held a market share of 55% in 2025.
Liquid biopsy is a minimally invasive diagnostic test that detects cancer-related biomarkers, such as circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), or other molecules, in body fluids like blood. It helps in the early detection, monitoring, and treatment selection of cancer without the need for a surgical tissue biopsy. Liquid biopsies can also be used to track disease progression and identify treatment resistance over time.
Leading companies in the market include Guardant Health, Thermo Fisher Scientific Inc., Illumina Inc., F. Hoffmann-La Roche Ltd., and QIAGEN N.V. These companies are strengthening their market presence by advancing liquid biopsy technologies, expanding their molecular diagnostics portfolios, and enhancing comprehensive genomic profiling capabilities. They are focused on improving biomarker detection sensitivity, increasing the accuracy of cancer diagnostics, and broadening the clinical applications of liquid biopsy across cancer screening, treatment selection, and disease monitoring.
The rising global burden of cancer is a major driver of growth in the liquid biopsy market. According to the American Cancer Society, approximately 19 million new cancer cases and 10 million cancer-related deaths occur worldwide each year, excluding non-melanoma skin cancer. Furthermore, the organization estimates that, without significant intervention, cancer incidence could surpass 33 million cases and mortality could reach 18 million deaths annually by 2050, largely due to population growth and aging. As cancer prevalence increases, healthcare systems are placing greater emphasis on early detection, continuous disease monitoring, and personalized treatment strategies to improve patient outcomes. Liquid biopsy has emerged as a valuable diagnostic tool in this landscape because it offers a minimally invasive method for detecting and monitoring cancer through biomarkers such as circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs). The technology enables earlier diagnosis, real-time assessment of treatment response, and detection of disease recurrence, reducing the need for repeated tissue biopsies. Moreover, the high incidence of lung cancer the most commonly diagnosed cancer and the leading cause of cancer deaths globally, accounting for approximately 1.8 million deaths annually further supports the adoption of liquid biopsy solutions, particularly for precision oncology applications.
Additionally, the growing preference for non-invasive diagnostic methods is a significant driver of the liquid biopsy market. Traditional tissue biopsies often require surgical or needle-based procedures, which can be painful, carry procedural risks, and may not always be feasible, particularly for patients with hard-to-reach tumors or advanced-stage cancers. As healthcare providers and patients increasingly prioritize safer and more convenient diagnostic approaches, demand for liquid biopsy technologies continues to rise. Liquid biopsy offers a minimally invasive alternative by analyzing cancer-related biomarkers, such as circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and extracellular vesicles, from blood or other bodily fluids. This approach reduces patient discomfort, lowers the risk of complications, and allows for repeated sample collection over the course of treatment. The ability to perform serial testing enables clinicians to monitor disease progression, assess treatment effectiveness, and detect recurrence in real time. Additionally, advancements in molecular diagnostics and precision medicine are further accelerating the adoption of liquid biopsy, making it an increasingly preferred tool for early cancer detection and personalized disease management.
Liquid Biopsy Market Trends
Liquid Biopsy Market Analysis
Based on the product, the liquid biopsy market is segmented into consumables, instruments, and services. The consumables segment is further sub-segmented into kits and reagents, and assay and panels. The consumables segment accounted for the highest market share of 58.9% in 2025.
Based on biomarkers, the liquid biopsy market is segmented into circulating tumor cells (CTC), circulating tumor DNA, cell-free DNA, extracellular vesicles, and other biomarkers. The circulating tumor cells segment held the largest share of 38.5% in 2025.
Based on the disease indication, the liquid biopsy market is segmented into cancer and non-cancer. Cancer is further segmented into lung cancer, breast cancer, colorectal cancer, prostate cancer, and other applications. Similarly, the non-cancer segment is further segmented into non-invasive prenatal testing, organ transplantation, and infectious disease testing. The cancer segment accounted for the highest market share of 85.9% in 2025.
Based on the clinical application, the liquid biopsy market is segmented into treatment monitoring, prognosis and recurrence monitoring, treatment selection, and diagnosis and screening. The treatment monitoring segment accounted for the highest market share and was valued at USD 2.5 billion in 2025.
Based on technology, the liquid biopsy market is segmented into multi-gene parallel analysis (NGS), and single gene analysis (PCR microarrays). Multi-gene parallel analysis (NGS) dominates the market with a share of about 75.9% in 2025.
Based on the end use, the liquid biopsy market is segmented into hospitals, research laboratories, clinical laboratories, and other end users. The hospitals segment accounted for the highest market share of 42.2% in 2025.
North America Liquid Biopsy Market
The North America region accounted for 40.8% of the market in 2025. The market in North America is experiencing robust expansion.
The U.S. market was valued at USD 1.6 billion and USD 1.8 billion in 2022 and 2023, respectively. The market size reached USD 2.3 billion in 2025, growing from USD 2 billion in 2024, and is anticipated to grow at a CAGR of 12% from 2026 to 2035.
Europe Liquid Biopsy Market
Europe market accounted for USD 1.9 Billion in 2025 and is anticipated to show lucrative growth over the forecast period.
Asia Pacific Liquid Biopsy Market
The Asia Pacific region is projected to show a lucrative growth of about 6.5% during the forecast period.
Latin America Liquid Biopsy Market
The Latin America market is experiencing robust growth over the analysis timeframe.
Middle East and Africa Liquid Biopsy Market
The Middle East and Africa (MEA) market is experiencing robust growth over the analysis timeframe.
Liquid Biopsy Market Share
Liquid Biopsy Market Companies
Few of the prominent players operating in the liquid biopsy industry include:
Guardant Health specializes in precision oncology through advanced liquid biopsy solutions. Its Guardant360 platform enables comprehensive genomic profiling and sensitive detection of actionable cancer biomarkers, supporting personalized treatment decisions and disease monitoring.
Illumina is a leading provider of next-generation sequencing technologies that power liquid biopsy testing. Its sequencing platforms and oncology-focused assays facilitate highly sensitive ctDNA analysis for cancer detection, biomarker identification, and treatment monitoring.
QIAGEN offers integrated liquid biopsy workflows for the isolation and analysis of circulating biomarkers. Its automated sample preparation solutions and molecular testing technologies support accurate detection of genetic alterations for oncology research and clinical applications.
Market share 18%
Collective market share of top 5 players is 55%
Liquid Biopsy Industry News
The liquid biopsy market research report includes an in-depth coverage of the industry with estimates and forecast in terms of revenue in USD Million and from 2022 – 2035 for the following segments:
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Market, By Product
Market, By Biomarkers
Market, By Disease Indication
Market, By Clinical Application
Market, By Technology
Market, By End Use
The above information is provided for the following regions and countries:
Table of Contents
Chapter 1 Research Methodology
Chapter 2 Executive Summary
Chapter 3 Industry Insights
Chapter 4 Competitive Landscape, 2025
Chapter 5 Market Estimates and Forecast, By Product, 2022 – 2035 ($ Mn)
Chapter 6 Market Estimates and Forecast, By Biomarkers, 2022 – 2035 ($ Mn)
Chapter 7 Market Estimates and Forecast, By Disease Indication, 2022 – 2035 ($ Mn)
Chapter 8 Market Estimates and Forecast, By Clinical Application, 2022 – 2035 ($ Mn)
Chapter 9 Market Estimates and Forecast, By Technology, 2022 – 2035 ($ Mn)
Chapter 10 Market Estimates and Forecast, By End Use, 2022 – 2035 ($ Mn)
Chapter 11 Market Estimates and Forecast, By Region, 2022 – 2035 ($ Mn)
Chapter 12 Company Profiles
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Research methodology, data sources & validation process
This report draws on a structured research process built around direct industry conversations, proprietary modelling, and rigorous cross-validation and not just desk research.
Our 6-step research process
1. Research design & analyst oversight
At GMI, our research methodology is built on a foundation of human expertise, rigorous validation, and complete transparency. Every insight, trend analysis, and forecast in our reports is developed by experienced analysts who understand the nuances of your market.
Our approach integrates extensive primary research through direct engagement with industry participants and experts, complemented by comprehensive secondary research from verified global sources. We apply quantified impact analysis to deliver dependable forecasts, while maintaining complete traceability from original data sources to final insights.
2. Primary research
Primary research forms the backbone of our methodology, contributing nearly 80% to overall insights. It involves direct engagement with industry participants to ensure accuracy and depth in analysis. Our structured interview program covers regional and global markets, with inputs from C-suite executives, directors, and subject matter experts. These interactions provide strategic, operational, and technical perspectives, enabling well-rounded insights and reliable market forecasts.
3. Data mining & market analysis
Data mining is a key part of our research process, contributing nearly 20% to the overall methodology. It involves analysing market structure, identifying industry trends, and assessing macroeconomic factors through revenue share analysis of major players. Relevant data is collected from both paid and unpaid sources to build a reliable database. This information is then integrated to support primary research and market sizing, with validation from key stakeholders such as distributors, manufacturers, and associations.
4. Market sizing
Our market sizing is built on a bottom-up approach, starting with company revenue data gathered directly through primary interviews, alongside production volume figures from manufacturers and installation or deployment statistics. These inputs are then pieced together across regional markets to arrive at a global estimate that stays grounded in actual industry activity.
5. Forecast model & key assumptions
Every forecast includes explicit documentation of:
✓ Key growth drivers and their assumed impact
✓ Restraining factors and mitigation scenarios
✓ Regulatory assumptions and policy change risk
✓ Technology adoption curve parameter
✓ Macroeconomic assumptions (GDP growth, inflation, currency)
✓ Competitive dynamics and market entry/exit expectations
6. Validation & quality assurance
The final stages involve human validation, where domain experts manually review filtered data to identify nuances and contextual errors that automated systems might miss. This expert review adds a critical layer of quality assurance, ensuring data aligns with research objectives and domain-specific standards.
Our triple-layer validation process ensures maximum data reliability:
✓ Statistical Validation
✓ Expert Validation
✓ Market Reality Check
Trust & credibility
Verified data sources
Trade publications
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Industry databases
Proprietary and third-party market databases
Regulatory filings
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Academic research
University studies and specialist institution reports
Company reports
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Expert interviews
C-suite, procurement leads, and technical specialists
GMI archive
13,000+ published studies across 30+ industry verticals
Trade data
Import/export volumes, HS codes, and customs records
Parameters studied & evaluated
Every data point in this report is validated through primary interviews, true bottom-up modelling, and rigorous cross-checks. Read about our research process →