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Demineralized Bone Matrix Market - By Product Type (Gel, Putty, Sponge, Fiber, Paste), Application (Dental, Craniomaxillofacial, Joint Reconstruction, Spinal Fusion), End-use (Hospitals, Specialty Clinics) – Global Forecast, 2024 - 2032

  • Report ID: GMI8338
  • Published Date: Feb 2024
  • Report Format: PDF

Demineralized Bone Matrix Market Size

Demineralized Bone Matrix Market size was valued at USD 832.8 million in 2023 and is estimated to grow at a CAGR of 4.9% from 2024 to 2032. Demineralized bone matrix (DBM) is a biologic material derived from human or animal bone tissue that has undergone a process to remove its mineral content, primarily calcium salts. DBM retains the structural integrity and biological properties of natural bone tissue, making it a valuable option in various medical applications, particularly in orthopedic and dental surgeries.

Demineralized Bone Matrix Market

The rising prevalence of orthopedic disorders has emerged as a significant public health concern worldwide. For instance, according to the World Health Organization (WHO), in July 2022, around 1.71 billion people were affected by musculoskeletal conditions worldwide. Therefore, there is an increasing demand for advanced treatments such as demineralized bone matrix in orthopedic surgeries to facilitate bone healing and reconstruction.

Furthermore, growing technological advancements in demineralized bone matrix are expected to propel the growth of the market in the forthcoming years. These include innovations such as  bone growth stimulators, a USD 875.2 million industry in 2021. The increasing patient base is also a contributing factor to the market expansion.

Demineralized Bone Matrix Market Trends

Technological advancements in demineralized bone matrix play a significant role in orthopedic and dental fields. These advancements aim to improve bone healing, increase surgical precision, enhance biocompatibility, and promote better integration with host tissues, leading to improved patient outcomes and reduced complications.

  • Advancements in processing techniques have led to more efficient demineralization methods while preserving the structural integrity and bioactivity of the bone matrix.
  • Furthermore, emerging technologies such as healthcare 3D printing along with tissue engineering, enables the customization and personalization of DBM grafts. This customization aligns with the unique anatomical and biomechanical needs of patients, ultimately enhancing the precision of surgical outcomes.
  • Moreover, advancements in DBM technology allows for customized formulations tailored to specific clinical applications and patient needs. This includes variations in particle size, shape, and composition to optimize handling and integration with surrounding tissues.

Demineralized Bone Matrix Market Analysis

Demineralized Bone Matrix Market, By Product Type, 2021 - 2032 (USD Million)

Based on product type, the market is classified into gel, putty sponge, fiber, paste, and other product types. The gel segment held a market size of USD 112.1 million in 2023.

  • Gel incorporation improves the handling characteristics of DBM, making it easier for surgeons to mold and shape the material to fit specific defects or anatomical structures during surgical procedures.
  • Furthermore, incorporating gel into demineralized bone matrix significantly improves its ability to adhere to surrounding tissues and bone surfaces, thereby increasing the stability and longevity of the graft at the implantation site.
  • Moreover, the use of gel formulations provides the flexibility to adjust rheological properties and composition to meet precise clinical requirements or patient needs. This customization enables the creation of tailored delivery systems optimized for various surgical procedures and anatomical locations, thereby fostering the segment growth.


Demineralized Bone Matrix Market, By Application (2023)

Based on application, the demineralized bone matrix market is bifurcated into dental applications, craniomaxillofacial, joint reconstruction, spinal fusion, and other applications. The joint reconstruction segment is estimated to account for a market size of USD 280 million by 2032.

  • Demineralized bone matrix harnesses growth factors and proteins that activate the body's innate bone-forming cells, fostering the generation of new bone and fostering seamless integration of the graft with the existing bone structure.
  • Further, DBM offers a structural framework for bone formation, facilitating the migration of osteogenic cells and encouraging the deposition of new bone tissue.
  • DBM undergoes meticulous processing and sterilization protocols to ensure safety and minimize the potential for disease transmission, establishing it as a dependable choice for joint reconstruction surgeries and thus propel the segmental market growth.

Based on end-use, the demineralized bone matrix market is categorized into hospitals, ambulatory surgical centers, specialty clinics, and other end-users. The hospitals segment accounted for around USD 364.4 million revenue in 2023.

  • Hospitals provide patients with cutting-edge treatment options utilizing DBM, ensuring access to efficient bone regeneration procedures tailored for orthopedic and dental conditions.
  • Further, integrating DBM into surgical protocols results in enhanced patient outcomes during bone grafting procedures, including accelerated bone healing, minimized complication rates, and optimized functional recovery.
  • Thus, hospitals equipped with advanced facilities ensure proper storage, handling, and application of DBM, maintaining its effectiveness and safety throughout the treatment process, thereby contributing to the growth of the market.


North America Demineralized Bone Matrix Market, 2020 - 2032 (USD Million)

North America demineralized bone matrix market accounted for USD 337.5 million revenue in 2023 and is predicted to witness substantial market growth.

  • The presence of a sophisticated healthcare infrastructure, rising prevalence of orthopedic conditions, ongoing technological advancements, and rising number of spinal fusion and dental surgeries, have all contributed to the increasing demand for DBM products.
  • For instance, according to National Center for Biotechnology Information (NCBI) in December 2021, fusion surgery emerged as one of the predominant surgical interventions for spinal conditions. The study revealed an annual incidence of around 400,000 spinal fusion procedures in the U.S, amounting to an estimated expenditure of USD 32 billion.
  • Furthermore, favorable reimbursement policies and government initiatives aimed at advancing orthopedic care and research further stimulate market growth for demineralized bone matrix products in North America.

Demineralized Bone Matrix Market Share

The demineralized bone matrix industry is competitive in nature, with several large multinationals and small and mid-sized companies competing in the industry. The development and launch of novel advanced devices based on different technologies is a key market strategy. Some of the leading industry players including, RTI Surgical, Inc., Stryker, Medtronic plc among others have a notable presence in the market.

Demineralized Bone Matrix Market Companies

Some of the eminent market participants operating in the demineralized bone matrix industry include:

  • Exactech, Inc.
  • Halma plc
  • Hans Biomed Corporation Ltd
  • Institut Straumann AG
  • Johnson & Johnson
  • Medtronic plc          
  • RTI Surgical, Inc.     
  • Seaspine Holdings Corporation
  • Stryker Corporation
  • Xtant Medical Holdings, Inc.
  • Zimmer Biomet Holdings, Inc.

Demineralized Bone Matrix Industry News

  • In July 2021, RTI Surgical acquired Exactech’s Optecure, cleared demineralized bone matrix used as a bone graft extender in spine, pelvis, and extremities. The acquisition complemented RTI Surgical’s existing portfolio of bone graft substitutes, bolstering its market position.
  • In November 2020, Stryker's successfully completed the acquisition of Wright Medical Group, a medical device company specializing in biologics and extremities. This acquisition expanded Stryker's orthopedic solutions portfolio, enriching its offerings to customers with a wider array of products and services.

The demineralized bone matrix market research report includes an in-depth coverage of the industry with estimates & forecast in terms of revenue in USD Million from 2018 to 2032 for the following segments:

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Market, By Product Type

  • Gel
  • Putty
  • Sponge
  • Fiber
  • Paste
  • Other product types

Market, By Application

  • Dental applications   
  • Craniomaxillofacial            
  • Joint reconstruction           
  • Spinal fusion
  • Other applications

Market, By End-use

  • Hospitals
  • Ambulatory surgical centers                  
  • Specialty clinics       
  • Other end-users

The above information is provided for the following regions and countries:

  • North America
    • U.S.
    • Canada
  • Europe
    • Germany
    • UK
    • France
    • Italy
    • Spain
    • Rest of Europe
  • Asia Pacific
    • China
    • Japan
    • India
    • Australia
    • South Korea
    • Rest of Asia Pacific
  • Latin America
    • Brazil
    • Mexico
    • Argentina
    • Rest of Latin America
  • Middle East and Africa
    • Saudi Arabia
    • South Africa
    • UAE
    • Rest of Middle East and Africa
Authors: Mariam Faizullabhoy, Gauri Wani

Frequently Asked Questions (FAQ) :

Demineralized bone matrix market size was USD 832.8 million in 2023 and is expected to register 4.9% CAGR from 2024-2032 owing to the rising prevalence of orthopedic disorders emerging, as a significant public health concern worldwide.

The gel segment recorded USD 112.1 million in 2023 and is expected to register an appreciable CAGR from 2024-2032 due to its ability to adhere to surrounding tissues and bone surfaces, thereby increasing the stability and longevity of the graft at site.

North America demineralized bone matrix industry reached USD 337.5 million in 2023 and is expected to register a commendable CAGR from 2024-2032 due to the presence of a sophisticated healthcare infrastructure and rising prevalence of orthopedic conditions in the region.

Institut Straumann AG, Johnson & Johnson, Medtronic plc, RTI Surgical, Inc., Seaspine Holdings Corporation, Stryker Corporation, Xtant Medical Holdings, Inc., and Zimmer Biomet Holdings, Inc., are some of the major demineralized bone matrix companies worldwide.

Demineralized Bone Matrix Market Scope

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Premium Report Details

  • Base Year: 2023
  • Companies covered: 11
  • Tables & Figures: 221
  • Countries covered: 22
  • Pages: 178
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