Bone Void Fillers Market - By Material Type, By Form, By Application, By End Use - Global Forecast, 2025 - 2034

Bone Void Fillers Market Size

The global bone void fillers market was valued at USD 3.6 billion in 2024. The market is expected to grow from USD 3.8 billion in 2025 to USD 7 billion in 2034, at a CAGR of 6.9% during the forecast period, according to the latest report published by Global Market Insights Inc.

The bone void fillers market is experiencing robust growth, primarily driven by the increasing volume of orthopedic and trauma surgeries and the rising incidence of bone-related conditions, including osteoporosis and fracture-associated defects. For instance, the total number of orthopedic surgeries in the period 2001–2022 was 1.5 million, of which 189,881 were hip replacement surgeries; 51,035 were knee replacement surgeries; 11,085 were revision hip arthroplasty; 1497 were revision knee arthroplasty; 541,440 were operated fractures; and 16,418 were operated bone tumors. The growth rates of surgical interventions are hip replacement surgery, 8.2%; total knee replacement surgery, 19.5%; revision hip arthroplasty, 9.4%; and revision knee arthroplasty, +28.6%. Such a high volume of orthopedic surgeries increases the demand for bone void fillers to effectively manage the procedures and increase success rates, thus driving the demand for bone void fillers.
 

Bone void filler is a material used to fill and support gaps or defects in bones that occur due to fractures, surgeries, infections, or tumor removal. These help the bone to heal by providing structural support and a scaffold for new bone growth. Key players driving the growth of the market include medical device and orthopedic companies such as Stryker, Zimmer Biomet, and DePuy Synthes, which offer a wide range of synthetic and biologic graft substitutes. These companies play critical roles in product innovation, surgeon training, regulatory approvals, and expanding global distribution networks, thereby accelerating the adoption and expansion of bone void fillers worldwide.
 

Between 2021 and 2023, the bone void fillers market witnessed considerable growth, driven by increased surgical volumes, a rising geriatric population, and rising access to advanced biomaterials. For instance, the global market was valued at about USD 2.9 billion in 2021 and reached around USD 3.4 billion in 2023. This growth can be majorly attributed to the rising incidence of bone disorders and trauma, a rapid shift toward minimally invasive surgery, and the availability of improved synthetic and biologic bone void fillers that reduce autograft/allograft dependency.
 

The bone void filler market refers to the global industry focused on biomaterials used to fill bone defects or voids resulting from trauma, surgery, or disease. These materials support bone regeneration, structural stability, and natural healing, often serving as alternatives or adjuncts to bone grafts.
 

Bone Void Fillers Market Trends

• A key trend in the bone void fillers industry is the growing shift from traditional autografts and allografts to synthetic and bioactive bone void fillers. These materials, such as calcium phosphate, bioactive glass, and composite scaffolds, offer predictable resorption rates, reduced infection risk, and improved biocompatibility. Their consistency, availability, and safety profile make them more suitable for large-scale clinical use, especially in orthopedic and trauma surgeries.
   
• Additionally, there is a growing adoption of injectable bone void fillers due to their ease of use in minimally invasive procedures. They can be molded or injected directly into bone defects, reducing surgical time, incision size, and patient recovery periods. This aligns with the broader healthcare shift toward outpatient and faster-healing treatment approaches, particularly in aging and trauma-prone populations.
   
• Furthermore, the increasing prevalence of bone-related disorders, trauma injuries, and degenerative skeletal diseases is a major catalyst for the bone void fillers (BVF) market. As global life expectancy rises and urbanization accelerates, the burden of bone fractures and orthopedic defects continues to expand across both developed and emerging regions.
   
• According to the World Health Organization (WHO), there were 178 million new fractures globally in 2019, marking a 33% increase since 1990, alongside 455 million cases of acute or chronic bone injury symptoms.
   
• Similarly, in Europe, new fragility fractures are projected to increase by 23% between 2017 and 2030, from 2.7 million to 3.3 million cases across major EU6 countries. In Italy, fragility fractures are expected to rise from 0.6 million to nearly 0.7 million during the same period (International Osteoporosis Foundation). As the number of fractures and bone defects continues to rise, surgeons and hospitals increasingly demand biocompatible, osteoconductive, and bioresorbable fillers that can seamlessly integrate with natural bone tissue. The growing clinical emphasis on faster healing, reduced donor site morbidity, and improved post-surgical functionality is fueling sustained market expansion.
   
• Also, technological innovations such as antibiotic-loaded bone void fillers are gaining traction. Such fillers allow localized drug release directly at the surgical site, reducing reliance on systemic antibiotics and lowering the risk of post-operative complications. This trend is particularly important for complex fractures and osteomyelitis management.
   
• Moreover, expanding applications of bone void fillers are further boosting market growth. Bone void fillers are increasingly being used beyond standard fractures, particularly in tumor resection surgeries, spinal reconstruction, and complex trauma repairs. Their role in stabilizing bone defects after cancer-related bone removals and correcting non-unions is expanding clinical demand.
   
• Thus, as orthopedic oncology and spine surgery volumes increase, the need for reliable bone defect management solutions will continue to rise, further driving market growth.
   

Bone Void Fillers Market Analysis

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Based on the material type, the global market is segmented into demineralized bone matrix, calcium sulfate, collagen matrix, tricalcium phosphate/calcium, and other material types. The demineralized bone matrix segment has asserted its dominance in the market by securing a significant market share of 36.1% in 2024 and is anticipated to grow at a CAGR of 6.1% over the forecast years.
 

• The demineralized bone matrix segment leads the market owing to its excellent osteoinductive potential, biocompatibility, and clinical versatility. Derived from processed allograft bone, DBM retains essential organic components such as collagen, growth factors, and bone morphogenetic proteins (BMPs), which play a critical role in stimulating new bone growth and enhancing graft integration. Its adaptability in multiple delivery forms, such as putty, paste, gel, and strips, offers surgeons greater convenience during orthopedic, trauma, and spinal fusion procedures.
   
• DBM has become a preferred alternative to autografts, as it eliminates donor-site morbidity, reduces surgical time, and minimizes post-operative complications. The segment’s growth is further supported by the rising number of spinal fusion and reconstructive surgeries, increasing use of biologic bone repair materials, and growing clinician awareness regarding DBM’s regenerative potential.
   
• The tricalcium phosphate/calcium phosphate-based filler material, on the other hand, held the second largest market share of 29%, driven by its excellent biocompatibility, osteoconductivity, and predictable resorption profiles. Calcium phosphate-based fillers, including α-TCP and β-TCP, provide structural scaffolds that facilitate bone cell proliferation and gradual replacement with native bone. These fillers are extensively used in spinal fusion, fracture repair, joint reconstruction, and dental implantology, serving as synthetic alternatives to autografts and allografts.
   

Based on the form, the global bone void fillers market is classified into gel, granules, paste/ injectable, putty, and other forms. The putty segment accounted for the highest market revenue of USD 1.5 billion in 2024 and is projected to grow at a CAGR of 7.2% during the analysis period.
 

• The putty form has emerged as the preferred choice among surgeons owing to its superior handling characteristics, adaptability, and ease of application in complex or irregular bone defects.
   
• Unlike granular or rigid alternatives, bone void filler putties provide a moldable, cohesive texture, allowing precise contouring and placement, particularly advantageous in craniofacial reconstruction, spinal fusion, orthopedic trauma, and dental surgeries.
   
• On the other hand, the paste/injectable segment is anticipated to witness growth at a CAGR of 7.4% over the forecast period, driven by its precise placement, adaptability, and suitability for minimally invasive surgeries.
   
• These formulations allow surgeons to inject or mold the material directly into bone defects, ensuring accurate filling in confined or irregular anatomical spaces such as spinal, craniofacial, and trauma sites.
   

Based on the application, the global bone void fillers market is classified into spine fusion, bone fracture, joint reconstruction, dental / cranio-maxillofacial surgery (CMF), and other applications. The spine fusion segment accounted for the highest market revenue of USD 2 billion in 2024 and is projected to grow at a CAGR of 7.2% during the analysis period.
 

• The spinal fusion segment represents one of the most significant and rapidly expanding areas of application within the market.
   
• Growth is primarily driven by the rising prevalence of degenerative spine disorders, traumatic spinal injuries, and age-related conditions such as osteoporosis, disc degeneration, and spondylosis.
   
• According to the North American Spine Society (NASS), over 450,000 spinal fusion surgeries are performed annually in the U.S., a figure expected to rise with the growing elderly population and improved diagnostic awareness of spinal pathologies.
   
• With rising procedural volumes, increasing technological sophistication, and expanding clinical evidence supporting bioactive fillers, the spinal fusion segment is expected to remain a major driver of market growth and innovation over the coming decade.
   
• On the other hand, the dental / cranio-maxillofacial surgery (CMF) segment is anticipated to witness high growth at a CAGR of 7.7% between 2025 – 2034.
   
• The segmental growth is driven by facial trauma, dental implant procedures, congenital craniofacial anomalies, and cosmetic reconstructive surgeries. According to NIH, there are over 10.7 million facial fracture cases, with men disproportionately affected (80.4% of cases; male: female ratio 4.1:1), while senior citizens and children account for 5.7% of cases.
   
• Similarly, the increasing volume of dental implants is also boosting filler demand, with over 12 million implants sold globally per year (MDPI).
   

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Based on end use, the global bone void fillers market is classified into hospitals, specialty clinics, ambulatory surgical centers, and other end users. The hospitals segment held a market share of 52.1% in 2024 and is projected to grow at a CAGR of 6.7% during the analysis period.
 

• Hospitals remain the primary centers for complex orthopedic, trauma, and spinal surgeries, where bone void fillers are extensively utilized to promote bone regeneration, enhance implant stability, and accelerate post-surgical recovery.
   
• Their dominance stems from the high procedural volume, access to advanced surgical infrastructure, and the presence of specialized orthopedic and neurosurgical teams capable of performing intricate bone reconstruction procedures.
   

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North America Bone Void Fillers Market
 

The North America market dominated the global bone void fillers industry with a market share of 48.9% in 2024.
 

• North America holds a high market share in the bone void fillers market due to its well-established healthcare infrastructure, high volume of orthopedic and trauma surgeries, and strong presence of leading market players offering advanced bone graft substitutes and minimally invasive solutions.
   
• The region benefits from early adoption of innovative biomaterials, widespread use of injectable and bioactive fillers, and significant investments in R&D and clinical studies.
   
• Additionally, the growing aging population, higher incidence of osteoporosis and sports-related injuries, and favorable reimbursement policies further support strong market demand.
   

The U.S. bone void fillers market was valued at USD 1.3 billion and USD 1.4 billion in 2021 and 2022, respectively. The market size reached USD 1.6 billion in 2024, growing from USD 1.5 billion in 2023.
 

• The U.S. holds a dominant position in the global market driven by significant orthopedic procedure volumes and high adoption of bone void fillers in the country.
   
• For instance, as per the CDC, annually about 300,000 hip-fracture hospitalizations among older adults (age 65+) are reported, of which approximately 88% are fall-related. Furthermore, the volume of orthopedic procedures in the U.S., which directly drives demand for bone void fillers, in 2022 was estimated at ~18.6 million.
   
• These data highlight the large procedural base and high incidence of bone-injury related care in the U.S., driving the region’s dominant share in bone void filler adoption and market growth.
  
   

Europe Bone Void Fillers Market
 

Europe market accounted for USD 928 million in 2024 and is anticipated to show lucrative growth over the forecast period.
 

• Europe holds a substantial share of the global bone void fillers industry, driven by a combination of aging populations, high incidence of fractures and musculoskeletal disorders, and widespread access to advanced orthopedic care.
   
• The region benefits from a collaborative ecosystem involving academic institutions, research organizations and biotechnology companies that accelerates the development and adoption of bone fillers.
   

Germany dominates the Europe bone void fillers market, showcasing strong growth potential.
 

• Germany holds a high market share in the Europe market due to its large volume of orthopedic and trauma surgeries, strong hospital infrastructure, and early adoption of advanced biomaterials.
   
• The country has one of the highest proportions of elderly individuals in Europe, which contributes to a greater incidence of osteoporosis-related fractures and joint degeneration requiring bone repair procedures.
   
• Moreover, the country is home to several leading orthopedic device manufacturers and research institutions, supporting ongoing innovation and clinical use of synthetic, bioactive, and antibiotic-eluting bone void fillers.
  
   

Asia Pacific Bone Void Fillers Market
 

The Asia Pacific market is anticipated to grow at the highest CAGR of 7.4% during the analysis timeframe.
 

• The Asia Pacific region is poised for high growth in the bone void fillers industry, driven by a rapidly growing geriatric population, rising disease burden, and expanding healthcare infrastructure.
   
• For example, A staggering 319 million people aged 50 and over in the Asia Pacific are projected to be at high risk of osteoporotic fracture within the next two decades, according to data from the Asia Pacific Consortium on Osteoporosis (APCO).
   
• Additionally, as per the NIH, in 2021, fractures in Asia reached 91.3 million incident cases and 232.7 million prevalent cases, reflecting a very large procedural base for bone repair interventions.
   
• Because these large patient pools and rising surgical / fracture-care demand translate directly into more need for bone void fillers, the Asia Pacific market presents a significant growth opportunity for manufacturers and service providers.
   

China bone void fillers market is estimated to grow with a significant CAGR, in the Asia Pacific market.
 

• China is emerging as a strong growth market for bone void fillers, due to its rapidly aging population, rising incidence of bone injuries and orthopedic disorders, and expanding healthcare infrastructure.
   
• With more hospitals upgrading to advanced surgical technologies and increasing numbers of trauma and spinal surgeries, the demand for synthetic and bioactive bone void filler solutions is growing.
   
• Additionally, local manufacturers are starting to introduce injectable and antibiotic-loaded fillers, supporting broader adoption and driving competition in the region.
  
   

Latin American Bone Void Fillers Market
 

Brazil leads the Latin American market, exhibiting remarkable growth during the analysis period.
 

• Brazil is seeing an increase in fracture treatments and orthopedic surgeries due to rising road accidents and sports injuries, which is boosting the adoption of bone void fillers in both public and private hospitals.
   
• Additionally, expansion of specialized surgical centers, along with greater availability of synthetic and bioactive bone graft substitutes, is supporting wider clinical use and market growth across the country.
   

Middle East and Africa Bone Void Fillers Market
 

Saudi Arabia market is expected to experience substantial growth in the Middle East and Africa bone void fillers industry in 2024.
 

• Saudi Arabia’s increasing number of road traffic accidents and rapidly expanding orthopedic and spine surgery sectors is creating greater demand for bone void fillers to manage bone defects and fracture repairs.
   
• With significant public-sector spending under initiatives like Vision 2030 to upgrade healthcare infrastructure and adopt advanced medical devices, Saudi Arabian hospitals are increasingly investing in synthetic and injectable bone repair materials, facilitating market growth.
   

Bone Void Fillers Market Share

The global bone void fillers industry is moderately consolidated, with leading orthopedic and medical device companies dominating the space, while innovation continues to thrive among. Top 5 players such as Stryker Corporation, DePuy Synthes (Johnson & Johnson), Zimmer Biomet, Medtronic, and Arthrex hold a combined market share of 68.8% in the global bone void fillers market. These players are continuously investing in research and development to expand their pipelines and enhance their product pipelines. The market also sees strategic partnerships, mergers, and acquisitions aimed at accelerating the commercialization of novel products and accessing new markets.
 

Additionally, smaller players and niche biotech firms contribute by focusing on specialized products and cutting-edge technologies. This dynamic environment fosters rapid technological advancements and competitive differentiation, driving the overall growth and diversification of the market.
 

Bone Void Fillers Market Companies

Prominent players operating in the bone void fillers industry are as mentioned below:
 

• Abyrx
• Acumed
• Arthrex
• Baxter International
• Bioventus
• Bonesupport
• DePuy Synthes (Johnson & Johnson)        
• Medline
• Medtronic
• Stryker        
• Zimmer Biomet
   
• Stryker Corporation

Stryker Corporation is a key player in bone void fillers, holding a substantial market share of 23.7% in the global market. The company offers well-established products such as Vitoss (a highly porous β-TCP scaffold that supports natural bone regeneration) and Pro-Dense (an injectable, triphasic bone graft that provides both immediate structural support and gradual resorption for long-term healing). Stryker’s competitive advantage comes from its integration with a large orthopedic implant and surgical solutions portfolio, extensive surgeon training programs, and a global distribution network, which together drive widespread clinical adoption and reinforces its leadership in the bone repair and regeneration market.
 

• DePuy Synthes (Johnson & Johnson)

DePuy Synthes, part of Johnson & Johnson MedTech, maintains a strong role in the bone void fillers market through its comprehensive orthopedic and trauma product ecosystem, which allows surgeons to use bone repair materials alongside fixation systems, implants, and reconstruction tools from a single platform. Its global reach, long-standing surgeon relationships, and continuous clinical training programs help drive widespread adoption, while its ability to bundle bone void fillers with complete surgical solutions provides a competitive advantage in hospitals and large health systems.
 

Bone Void Fillers Industry News

• In September 2023, Abyrx received additional FDA clearance for its MONTAGE Settable Bone Putty for use in cardiothoracic surgery following sternotomy, marking the first approval of a settable bone putty for sternal applications.
   
• In July 2021, Bioventus launched OsteoAMP Select Flowable, an allograft substitute optimized for minimally invasive surgeries, applicable in spine and foot & ankle procedures. This product launch expanded Bioventus offerings in the bone void fillers market by introducing a versatile graft material for orthopedic use.
   
• In May 2024, Bonesupport partnered with AKVA Surgical to launch the CERAMENT portfolio in Australia, including CERAMENT Bone Void Filler and CERAMENT G. This collaboration extended Bonesupport’s geographic reach.
   
• In March 2024, Bonesupport received FDA clearance for CERAMENT Bone Void Filler for use in spinal interbody fusion procedures. This regulatory milestone expanded CERAMENT’s clinical applications and strengthened Bonesupport’s position in the U.S. market.
   
• In August 2024, LifeNet Health launched PliaFX Pak, a new bone allograft combining mineralized bone chips and moldable demineralized fibers, in collaboration with Johnson & Johnson MedTech.
   

The bone void fillers market research report includes in-depth coverage of the industry with estimates and forecast in terms of revenue in USD Million from 2021 – 2034 for the following segments:

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Market, By Material Type

• Demineralized bone matrix
• Calcium sulfate
• Collagen matrix
• Tricalcium phosphate/calcium phosphate based
• Other material types

Market, By Form

• Gel
• Granules
• Paste / injectable
• Putty
• Other forms

Market, By Application

• Spine fusion
• Bone fracture
• Joint reconstruction
• Dental / cranio-maxillofacial surgery (CMF)
• Other applications

Market, By End Use

• Hospitals
• Specialty clinics
• Ambulatory surgical centers
• Other end use

The above information is provided for the following regions and countries:

• North America
  • U.S.
  • Canada
• Europe
  • Germany
  • UK
  • France
  • Spain
  • Italy
• Asia Pacific
  • China
  • India
  • Japan
  • Australia
  • South Korea 
• Latin America
  • Brazil
  • Mexico
  • Argentina 
• Middle East and Africa
  • South Africa
  • Saudi Arabia
  • UAE