Bone Graft Substitutes Market - By Material Type [Allograft (DBM), Synthetic (Polymer, Ceramics, Composites)], Application (Spinal Fusion, Dental, Joint Reconstruction, Foot & Ankle, Craniomaxillofacial, Long Bone), End-use – Global Forecast, 2024 – 2032

Bone graft substitutes market Size

Bone Graft Substitutes Market size was valued at around USD 3 billion in 2023 and is estimated to expand at 6.6% CAGR from 2024 to 2032. This robust market growth can be attributed to various factors, including ongoing advancements in technology, increased awareness among patients and healthcare professionals, growing number of surgical procedures, and rising prevalence of orthopedic disorders, among other contributing factors.
 

Moreover, an overall increase in the incidences of orthopedic diseases, such as fractures, joint degeneration, and spinal issues, demands surgical procedures such as bone graft substitutes. The need for bone replacement and grafts increases as more orthopedic procedures are being performed, thus fostering the market growth. For instance, according to the American Academy of Physical Medicine and Rehabilitation, degenerative joint disease affects around 50% of adult individuals over 65 in the U.S. The disorder is associated with pain, loss of function, and decreased stamina, which can lead to weight gain and other impacts.
 

In addition, according to the statistics by World Health Organization (WHO), around 73% of patients with osteoarthritis are above the age of 55, with 60% of them are female. Additionally, continuous advancements in medical technology, such as development of synthetic bone graft materials, spine biologics, and tissue engineering, further enhance the efficacy and safety of bone transplant treatments.
 

Bone graft substitutes refer to medical materials used in orthopedic and dental procedures to facilitate bone healing, regeneration, or fusion. These materials are employed when there is a need to replace or augment bone tissue, such as in cases of fractures, spinal fusion surgeries, joint reconstruction, or dental procedures.
 

Bone Graft Substitutes Market Trends

The market are experiencing several notable trends that are shaping its growth and development. Factors such as rise in 3D printing technology, increasing use of allografts and xenografts, growing awareness of dental health and aesthetics, and a surging demand for minimally invasive surgical techniques, among other factors are propelling the industry expansion.
 

• Further, a growing trend toward minimally invasive surgical techniques are influencing the market to improve their efficiency and aid better patient experience. Patients and healthcare providers were increasingly preferring procedures that involve smaller incisions, less tissue disruption, and shorter recovery times.
   
• Moreover, ongoing research and development in biomaterials, including synthetic bone grafts and biologics, are driving innovation. Materials with enhanced biological properties and improved integration with host tissues are gaining notable importance in the industry.
   

Bone Graft Substitutes Market Analysis

Based on material type, the market is categorized into allograft, and synthetic. The allograft segment is further bifurcated into demineralized bone matrix (DBM) and other allografts. The synthetic segment is further divided into polymers, ceramics, composites, and bone morphogenic proteins (BMP). The allograft segment accounted for majority revenue share and was valued at around USD 2 billion revenue in 2023.
 

• Allografts are adaptable and can be utilized for a variety of orthopedic and dental procedures, such as spinal fusion, joint repair, trauma surgery, and dental implants. Their versatility for numerous medical conditions provides them with a popular option among surgeons. Allografts' flexibility increases their market value by allowing them to be used in a variety of medical procedures.
   
• Furthermore, allografts reduce the need for an additional surgical site, resulting in a shorter overall surgical time compared to autograft treatments. This is especially useful in situations when efficiency and shorter operating periods are important.
   
• The time-saving benefits of employing allografts could contribute to greater adoption, especially in situations requiring a faster surgical approach.

Based on application, the bone graft substitutes market is segmented into spinal fusion, dental, joint reconstruction, foot & ankle, craniomaxillofacial, and long bone. The spinal fusion segment accounted for 51.2% business share in 2023 and is anticipated to witness significant growth during the forecast period.
 

• The demand for spinal fusion procedures has risen owing to a growing number of spinal diseases such degenerative disc disease, spinal stenosis, and vertebral fractures. These medical conditions often require the use of bone transplants and substitutes to aid with fusion. The rising prevalence of spinal problems is a major driver for the use of bone graft substitutes in spinal fusion surgeries, thus contributing to market progression.
   
• Moreover, the adoption of spinal fusion surgeries is influenced by greater understanding among patients and healthcare professionals regarding the procedure's effectiveness in treating specific spinal diseases. This awareness enhances the market for bone transplants and replacements used in spinal fusion procedures. Thus, more individuals choosing to have spinal fusions as a result of increased acceptance as well as awareness of the procedures' advantages drives growth in the market.
   

The bone graft substitutes market by end-use is categorized into hospitals, specialty clinics, and other end-users. The hospitals segment accounted for around USD 1.9 billion revenue size in 2023.
 

• Hospitals are experiencing a rise in the number of orthopedic surgeries, such as spinal fusion, joint reconstruction, and trauma surgeries, that often require the use of bone transplants and replacements. The rising incidence of musculoskeletal diseases contributes to the growing demand for orthopedic operations. The rising number of orthopedic procedures placed hospitals at the forefront of bone graft adoption, prompting the use of dependable and efficient graft materials.
   
• Additionally, governments and healthcare organizations are making significant investments in upgrading healthcare infrastructure, including surgical facilities within hospitals. The improvement of infrastructure facilitates the implementation of advanced surgical procedures, contributing to the demand for bone graft substitutes.

North America bone graft substitutes market accounted for USD 1.3 billion revenue in 2023 and is predicted to witness substantial market expansion.
 

• Orthopedic issues such as bone degeneration, fractures, and spinal abnormalities are prevalent in North America. The region's aging population incorporates to a spike in the incidence of these diseases, pulling up demand for bone transplants and substitutes. The growing number of orthopedic diseases produces a significant demand for bone grafts and replacements as surgical procedures are more common in the region.
   
• Furthermore, ongoing developments in biomaterials, tissue engineering, and surgical methods assist to produce new bone graft materials, that enhance their effectiveness in orthopedic and dentistry surgeries. A favorable environment for the adoption of novel bone graft solutions is fostered by the region's dedication to technological advances and research, which propels the market growth in the region.
   

Bone Graft Substitutes Market Share

The bone graft substitutes industry is competitive in nature, with several large multinationals and small and mid-sized companies competing in the industry. The development and launch of novel advanced products based on different technologies is among a key market strategy. Some of the leading industry players including Baxter International Inc., DePuy Synthes (Johnson & Johnson Inc.), Medtronic plc, Orthofix US LLC., Smith + Nephew, among others have a notable presence in the market.
 

Bone Graft Substitutes Market Companies

Some of the eminent market participants operating in the bone graft substitutes industry include:

• AlloSource
• Baxter International Inc.
• DePuy Synthes (Johnson & Johnson Inc.)
• Geistlich Pharma AG
• Medtronic plc
• NuVasive, Inc.
• Orthofix US LLC.
• OST Laboratories
• Smith + Nephew
• Stryker Corporation
• Zimmer Biomet Holdings, Inc.
   

Bone Graft Substitutes Industry News:

• In July 2023, Cerapedics Inc. announced that it has expanded its headquarters in the Denver metro area to support the growth of its products, which include the FDA-approved i-FACTOR bone graft for cervical spinal fusion and a next-generation product that is currently being evaluated for lumbar spinal fusion.
   
• In July 2021, Orthofix Medical Inc. has announced the official launch and first patient implantation of the fiberFUSE Strip, an innovative demineralized fiber bone-graft solution including cancellous bone. The fiberFUSE Strip is designed as a simple premade bone-graft strip for optimal use in posterior cervical, posterior lumbar, and degenerative spinal surgeries.
   

Bone graft substitutes market research report includes an in-depth coverage of the industry with estimates & forecast in terms of revenue in USD Million from 2018 to 2032 for the following segments:

Click here to Buy Section of this Report

Market, By Material Type

• Allograft
  • Demineralized bone matrix (DBM)
  • Other allografts
• Synthetic
  • Polymers
  • Ceramics
  • Composites
  • Bone morphogenic proteins (BMP)

Market, By Application

• Spinal fusion
• Dental
• Joint reconstruction
• Foot & ankle
• Craniomaxillofacial
• Long bone

Market, By End-use

• Hospitals
• Specialty clinics
• Other end-users

The above information is provided for the following regions and countries:

• North America
  • U.S.
  • Canada
• Europe
  • Germany
  • UK
  • France
  • Spain
  • Italy
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • Australia
  • South Korea
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • Argentina
  • Rest of Latin America
• Middle East and Africa
  • South Africa
  • Saudi Arabia
  • UAE
  • Rest of Middle East and Africa