Gene Synthesis Market Analysis

Gene Synthesis Market Analysis

By method, the gene synthesis market is classified into solid phase synthesis, PCR-based enzyme synthesis and chip-based synthesis. The solid phase synthesis segment accounted over 36.5% of the business share in 2022 and is projected to witness robust growth over the analysis timeframe. Solid-phase synthesis is increasingly utilised to generate canonical and modified polymers of nucleic acids, specifically DNA or RNA, making widely used technology in a variety of fields and research goals. Also, various advantages offered such as rapid generation of linear peptide intermediates, easy purification and precedent in the synthesis of large peptides among others are significantly contributing to the increasing adoption of solid phase synthesis.
 

By services, the gene synthesis market is divided into antibody DNA synthesis, viral DNA synthesis, and others. Antibody DNA synthesis segment is anticipated to grow at 18.8% throughout the forecast period. Antibody DNA synthesis is used to produce synthetic genes encoding for specific antibodies, which are then used in a variety of applications such as diagnostics, therapeutics, and research tools. Further, antibody DNA synthesis is particularly useful for developing large quantities of a specific antibody, as it allows researchers to produce a synthetic version of the gene that encodes for that antibody that be expressed in a host organism or in vitro system.
 

Based on application, the gene synthesis market is segmented into gene & cell therapy development, disease diagnosis, vaccine development and others. The gene & cell therapy development segment was valued around USD 716 million in 2022. Gene and cell therapy development is one of the most promising applications of gene synthesis and is rapidly expanding due to recent advancements in genome editing technology. Furthermore, genes that can be used to replace or modify a patient's defective or missing genes that can lead to the development of more effective and targeted therapies. Also, gene synthesis is used in the development of CAR-T cell therapies, which use genetically modified T cells to attack cancer cells, thereby propelling the market forecasts.
 

Gene synthesis market by end-use is classified as academic and research institutes, biopharmaceutical companies, contract research organizations. The academic and research institutes is projected to reach over USD 6.5 billion in 2032. Gene synthesis is becoming widely adopted in academic and research institutes owing to its numerous advantages. It enables customization that is essential for complex research studies that suffice the need of specific DNA sequences. The high accuracy of gene synthesis provides researchers with the flexibility to create complex DNA sequences that may be difficult or impossible to obtain through traditional cloning methods.
 

North America gene synthesis market accounted for over 38% revenue share in 2022 and is anticipated to grow at considerable growth rate during the forecast timeframe. This is attributed to several factors such as growing R&D investments, presence of key market players, CROs providing gene synthesis services among others is forecasted to boost the market size in North America region. Also, growing interest in synthetic biology research coupled with increasing research activities for the development of effective therapeutics will significantly proliferate the market outlook.