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Gene Synthesis Market - By Method, By Services, By Application, By Complexity, By End Use - Global Forecast, 2025 - 2034
Report ID: GMI5636
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Published Date: November 2025
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Report Format: PDF
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Authors: Mariam Faizullabhoy, Gauri Wani
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Base Year: 2024
Companies covered: 15
Tables & Figures: 121
Countries covered: 19
Pages: 160
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Gene Synthesis Market
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Gene Synthesis Market Size
The global gene synthesis market was valued at USD 951.9 million in 2024. The market is expected to reach from USD 1.1 billion in 2025 to USD 4.6 billion in 2034, growing at a CAGR of 16.9% during the forecast period, according to the latest report published by Global Market Insights Inc. The drivers include increased demand for synthetic biology, improvement in DNA synthesis technologies, increasing funding of genomic research, expansion of personalized medicine biomarkers, and applications in pharmaceutical and biotechnology industries.
The global gene synthesis market provides innovative solutions to biotechnology firms, pharmaceutical companies, academic institutions, and healthcare technology providers to enhance research accuracy, drug discovery services, and genetic analysis efficiency. Solutions include custom gene synthesis, cloning services, and DNA library construction, platforms that support advancements in synthetic biology, genomics, and personalized medicine.
Key players in the market include Thermo Fisher Scientific, GenScript, Twist Bioscience Corporation, Integrated DNA Technologies (IDT) (Danaher), Eurofins Genomics, and Azenta, Inc. These companies maintain a competitive edge through continuous innovation, global expansion, strategic collaborations, and substantial R&D investments to meet growing research demands and strengthen their market presence.
The market has increased from USD 472.1 million in 2021 and reached USD 766.3 million in 2023. The growth of the global gene synthesis market is primarily driven by advancements in synthetic biology, the rapid evolution of DNA synthesis technologies, and increasing demand across the biotechnology and pharmaceutical sectors. One of the major drivers is the expanding field of synthetic biology, which relies heavily on gene synthesis to engineer biological systems, develop novel biomolecules, and create sustainable bio-based products. This is further fueled by the growing focus on personalized medicine, where synthetic genes are used to develop patient-specific therapies, diagnostics, and vaccines.
Technological innovations, such as automated DNA synthesis platforms, error-correction techniques, have significantly improved synthesis accuracy, reduced turnaround time, and lowered costs making gene synthesis more accessible to academic and commercial researchers. Rising government and private funding in genomics and molecular biology research also play a crucial role in supporting large-scale gene synthesis projects for disease modeling, agricultural improvements, and industrial biotechnology.
Furthermore, the increasing application of gene synthesis in drug discovery and development, vaccine production, and antibody engineering continues to propel market growth. The COVID-19 pandemic demonstrated the potential of synthetic genes in accelerating vaccine design and therapeutic development, which continues to drive post-pandemic adoption. Strategic collaborations among leading players such as Thermo Fisher Scientific, GenScript, Twist Bioscience, Integrated DNA Technologies (IDT), Eurofins Genomics, and Azenta, Inc. are fostering innovation and expanding service portfolios. Additionally, the rising trend of outsourcing gene synthesis services by pharmaceutical and biotech companies to specialized providers enhances market scalability. Collectively, these factors are expected to sustain robust growth in the global gene synthesis market throughout the forecast period.
Gene synthesis is a laboratory technique used to artificially design and construct genes by assembling nucleotides (DNA sequences) without relying on a natural template. It enables precise creation of custom genetic material for applications in synthetic biology, drug discovery, genetic engineering, and molecular diagnostics, supporting research, biotechnology innovation, and therapeutic development.
14.6%
Collective market share in 2024 is 47.1%
Gene Synthesis Market Trends
Among the major factors driving the growth of the global market for gene synthesis are the rapid improvements in DNA synthesis technologies. These have greatly transformed research, diagnostics, and therapeutic development. Continuous innovation has driven speed, accuracy, and cost-efficiency into the process of gene synthesis, enabling wider adoption in pharmaceutical, biotechnology, and academic research circles.
Gene Synthesis Market Analysis
Based on the method, the gene synthesis market is segmented into solid-phase synthesis, PCR-based enzyme synthesis, and chip-based synthesis. The solid-phase synthesis segment has asserted its dominance in the market by securing a significant market share of 58.6% in 2024, as it offers high accuracy, scalability, and efficiency for long DNA sequences, making it ideal for large-scale commercial and research applications. The segment is expected to exceed USD 2.6 billion by 2034, growing at a CAGR of 16.5% during the forecast period.
On the other hand, the PCR-based enzyme synthesis segment is expected to grow with a CAGR of 17.7%. The growth of this segment can be attributed to the cost-effective amplification of short DNA fragments with high fidelity, supporting gene cloning and molecular diagnostics.
Based on services, the gene synthesis market is classified into antibody DNA synthesis, viral DNA synthesis, and other services. The antibody DNA synthesis segment dominated the market with a revenue share of 46.4% in 2024 and is expected to reach USD 2.2 billion within the forecast period.
Based on application, the gene synthesis market is classified into gene and cell therapy development, disease diagnosis, vaccine development and other applications. The gene and cell therapy development segment dominated the market with a revenue share of 44.1% in 2024 and is expected to reach USD 2.2 billion within the forecast period.
Based on complexity, the gene synthesis market is classified into standard gene synthesis and complex gene synthesis. The standard gene synthesis segment dominated the market with a revenue share of 67.6% in 2024 and is expected to reach USD 3 billion within the forecast period.
Based on end use, the gene synthesis market is classified into biopharmaceutical companies, academic & research institutes, and contract research organizations. The biopharmaceutical companies segment dominated the market with a revenue share of 45.5% in 2024 and is expected to reach USD 2.3 billion within the forecast period.
North America Gene Synthesis Market
North America dominated the gene synthesis market with the highest market share of 40.3% in 2024.
The U.S. gene synthesis market was valued at USD 177.1 million and USD 228.4 million in 2021 and 2022, respectively. In 2024, the market size grew to USD 359.2 million from USD 288.6 million in 2023.
Europe Gene Synthesis Market
Europe market accounted for USD 271 million in 2024 and is anticipated to show lucrative growth over the forecast period.
Germany dominates the European gene synthesis market, showcasing strong growth potential.
Asia Pacific Gene Synthesis Market
The Asia Pacific market is anticipated to grow at the highest CAGR of 18.2% during the analysis timeframe.
China gene synthesis market is estimated to grow with a significant CAGR in the Asia Pacific market.
Latin American Gene Synthesis Market
Brazil leads the Latin American market, exhibiting remarkable growth during the analysis period.
Middle East and Africa Gene Synthesis Market
Saudi Arabia market to experience substantial growth in the Middle East and Africa market in 2024.
Gene Synthesis Market Share
The market is highly competitive, with leading biotechnology and life sciences companies focusing on technological innovation, advanced synthesis platforms, and strategic collaborations to strengthen their market positions. Rising demand for synthetic biology applications, growing investments in genomics research, and increasing adoption of personalized medicine and gene therapies are driving companies to leverage R&D, automation, and next-generation sequencing integration to enhance synthesis accuracy and efficiency. Expanding applications in pharmaceuticals, industrial biotechnology, and academic research also encourage players to develop cost-effective, scalable, and customizable gene synthesis solutions while expanding their presence in emerging markets.
Key players include GenScript, Thermo Fisher Scientific, Twist Bioscience Corporation, Integrated DNA Technologies (IDT) (Danaher), and Eurofins Genomics, collectively accounting for 47.1% of the global market. These companies maintain leadership through extensive product portfolios, high-throughput synthesis capabilities, global distribution networks, and continuous advancements in custom gene synthesis, DNA library construction, and cloning services. Their dominance is further reinforced by strategic collaborations with academic institutions, pharmaceutical firms, and research organizations to enhance accessibility and adoption of advanced gene synthesis services.
Smaller and niche players are also gaining traction by focusing on specialized, high-precision, and cost-efficient synthesis services tailored to specific research or therapeutic applications. Competitive differentiation is increasingly defined by the ability to deliver highly accurate, scalable, and innovative solutions that meet evolving scientific demands. As the market evolves, competition is expected to intensify, with both established leaders and emerging firms pursuing continuous innovation, automation, and strategic partnerships to capture greater market share.
Gene Synthesis Market Companies
A few of the prominent players operating in the gene synthesis industry include:
GenScript leads the gene synthesis market with a share of 14.6% in 2024. The company offers highly customizable gene synthesis services with rapid turnaround, high-fidelity DNA assembly, comprehensive cloning and expression solutions, global logistics support, and continuous innovation in synthetic biology, enabling researchers to accelerate drug discovery, vaccine development, and molecular biology research efficiently.
Thermo Fisher Scientific combines a broad product portfolio, automated high-throughput gene synthesis platforms, integrated bioinformatics, and global distribution networks, providing scalable, precise, and reliable DNA synthesis solutions for academic, pharmaceutical, and industrial biotechnology applications.
Gene Synthesis Industry News:
The gene synthesis market research report includes an in-depth coverage of the industry with estimates and forecast in terms of revenue in USD Million from 2021 – 2034 for the following segments:
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Market, By Method
Market, By Services
Market, By Application
Market, By Complexity
Market, By End Use
The above information is provided for the following regions and countries: