DNA Synthesis Market Size - By Service (Oligonucleotide Synthesis, Gene Synthesis), Method (Solid Phase, PCR-Based), Application (Research & Development, Therapeutic), End-use (Academic & Research Institutes, Biopharmaceutical), Forecast 2024 - 2032

DNA Synthesis Market size

DNA Synthesis Market size was valued at USD 4.1 billion in 2023 and is expected to register a CAGR of 19.5% between 2024 and 2032. The growth of the market can be attributed to the growing demand for DNA synthesis for its utility in molecular biology, genetic engineering, and clinical diagnostics & therapeutics.
 

Rising disease burden globally coupled with growing demand for research in drug discovery and personalized medicine is positively impacting the market growth. Further, several technological advancements in the field of DNA synthesis and genomics in recent years, high R&D investments, and advanced services offered by market players are some major factors that will drive the market growth over the analysis period.
 

DNA synthesis is the process of artificially creating DNA molecules. It involves chemically synthesizing nucleotide sequences in the laboratory, that can be used for various applications such as genetic engineering, research, and biotechnology.
 

COVID-19 Impact

The COVID-19 pandemic disrupted the healthcare system worldwide, owing to strict lockdown and restrictions on transportation of raw materials that caused disruptions in the overall global supply chain. The initial phase of the pandemic observed a slight slowdown in some non-COVID-19-related research activities that rely on DNA synthesis. However, the COVID-19 pandemic positively impacted the DNA synthesis market growth at the later stage of the year. DNA synthesis played major role for the development of COVID-19 diagnostic tests and vaccines. Additionally, significant role of DNA synthesis in various aspects of research and development related to COVID-19 highlighted the importance of DNA synthesis in medical research for the development of new therapies, thereby positively influencing the overall market growth for the coming years.
 

DNA Synthesis Market Trends

Investments in DNA synthesis by market players have been increasing over the years as the field of synthetic biology and genetic engineering continues to advance. High investments in research to unveil novel technology will positively influence the market growth. For instance, in 2021, Molecular Assemblies received USD 25.8 million funding from Casdin Capital to enhance enzymatic DNA synthesis technology. Similarly, in March 2021, Twist Bioscience announced USD 100 million private placement investment from several investors, including Casdin Capital, Fidelity Management & Research Company, and Viking Global Investors to advance their DNA synthesis platform. Thus, the increasing investments in DNA synthesis industry is expected to fuel the market growth.
 

DNA Synthesis Market Restraint

Stringent government regulations and guidelines in DNA synthesis are put in place to ensure responsible and safe use of this powerful technology. DNA synthesis has the potential to revolutionize various fields, including medicine, agriculture, and biotechnology. However, it also carries certain risks, such as the creation of harmful pathogens or misuse for unethical purposes. Hence, governments require DNA synthesis facilities and researchers to obtain licenses and register with relevant authorities. Additionally, regulatory bodies may require regular reporting of DNA synthesis activities, including the DNA sequences synthesized, purpose of synthesis, and the quantities produced. Such stringent regulations and guidelines surrounding DNA synthesis may hinder the market growth to some extent.
 

DNA Synthesis Market Analysis

By service, the DNA synthesis market is classified into oligonucleotide synthesis and gene synthesis. Oligonucleotide synthesis segment dominated the market in 2022 with a revnue share of 52.6%. Increasing demand for synthetic biology is driving the demand for oligonucleotides. Oligonucleotides are essential tools for gene synthesis, DNA sequencing, and genetic engineering, supporting advancements in fields such as medicine and biotechnology. Moreover, companies are entering into strategic initiatives to launch novel products, which is expected to drive the segment. For instance, in October 2022, Bachem entered into collaboration with Eli-Lilly and Company for the development and manufacturing of APIs that are based on oligonucleotides. Such initiatives by market players will drive the segmental growth.
 

By method, the DNA synthesis market is classified into solid phase synthesis, PCR-based enzyme synthesis and chip-based synthesis. The solid phase synthesis segment accounted over 36.6% of the market share in 2022 and is projected to witness robust CAGR over the analysis timeframe. Solid-phase DNA synthesis allows researchers to design and synthesize DNA sequences with high precision and flexibility. It enables the creation of custom DNA molecules with specific sequences, lengths, modifications, and labelling, tailored to the needs of various applications. The method is highly efficient with quicker turnaround time. Additionally, solid-phase DNA synthesis can be easily scaled up to accommodate larger quantities of DNA. Such benefits associated with solid-phase synthesis method is expected to propel the segmental demand.
 

Based on application, the DNA synthesis market is bifurcated into research & development, diagnostics and therapeutics. The research and development segment held the largest share of 43.6% in 2022. DNA synthesis is a fundamental tool for biotechnology-based research. DNA synthesis is widely used in the discovery and development of new drugs. They are also utilized in the development of diagnostic tests for genetic diseases, infectious diseases, and cancer. For instance, in November 2021, DNAScript declared that it received a grant of USD 2.2 million from the National Human Genome Research Institute as a support fund for the development of next-generation printers that enzymatically print synthetic nucleotides. Thus, such aforementioned funding coupled with multiple applications of DNA synthesis in R&D activities will drive the market statistics.
 

DNA synthesis market by end-use is classified as academic & research institutes, biopharmaceutical companies, contract research organizations. The academic and research institutes is expected to reach over USD 11 billion by 2032. DNA synthesis plays a crucial role in academic and research institutes across various fields. Synthetic DNA enables customization that is essential for complex research studies. The high accuracy of DNA synthesis provides researchers with the flexibility to create complex DNA sequences that may be difficult or impossible to obtain through traditional cloning methods. Therefore, high adoption of DNA synthesis has revolutionized molecular biology research leading to new discoveries and breakthroughs, thereby contributing to the market expansion.
 

North America dominated the global DNA synthesis market with a revenue share of 38.4% in 2022. High market share is attributed to growing R&D investments and presence of key market players in the region. Also, initiatives by governments and collaborations between market players further strengthen the market growth. For instance, in April 2021, DNA Script entered into partnership with Moderna, Inc. with a USD 5 million grant from the U.S. Defense Advanced Research Projects Agency to develop a prototype for rapid mobile manufacturing of vaccines and therapeutics as part of the Defense Advanced Research Projects Agency's (DARPA) Nucleic Acids On-Demand World-Wide (NOW) Program. Therefore, constant support from government along with rising incidence of various chronic & infectious diseases as well as rising demand for effective diagnosis and treatment is expected to boost the market growth.
 

DNA Synthesis Market Share

Major market players operating in the DNA synthesis market include :

• Thermo Fisher Scientific, Inc.
• Twist Bioscience
• Bioneer Corporation
• Eton Bioscience
• LGC Biosearch Technologies
• IBA GmbH
• Eurofins Scientific
• Integrated DNA Technologies, Inc.
• Quintara Biosciences
• GenScript Biotech Corporation
• OriGene Technologies, Inc.
• Eurogentec
• ProMab Biotechnologies
• BIOMATIK
• ProteoGenix
• BOSTER antibody
• ELISA experts

These industry players majorly adopt various strategies including collaborations, acquisitions, mergers, and partnerships to create a global footprint and sustain market competition.
 

DNA Synthesis Industry News:

• In May 2023, GenScript Biotech Corporation launched its GenTitan Gene Fragments Synthesis service to expedite gene synthesis at lower cost. This is expected to help the company widen its service offerings and cater to a larger customer base.
   
• In January 2023, Twist Bioscience and Astellas entered into a multitarget antibody discovery research collaboration. This strategic collaboration aimed to discover antibodies against multiple targets of interest and curative therapies for patients suffering from diseases that lack treatment options. This strategy is expected to help the company to enhance its service offerings.
   

The DNA synthesis market research report includes an in-depth coverage of the industry with estimates & forecast in terms of revenue in USD from 2018 to 2032, for the following segments:

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By Service

• Oligonucleotide synthesis
  • Standard oligonucleotide synthesis
  • Custom oligonucleotide synthesis
• Gene synthesis
  • Custom gene synthesis
  • Gene library synthesis

By Method

• Solid phase synthesis
• PCR-based enzyme synthesis 
• CHIP-based DNA synthesis

By Application

• Research and Development
• Diagnostics
• Therapeutics

By End Use

• Biopharmaceutical companies
• Academic and research institutes
• Contract research organizations

The above information is provided for the following regions and countries:

• North America
  • U.S.
  • Canada
• Europe
  • Germany
  • UK
  • France
  • Spain
  • Italy
  • Rest of Europe
• Asia Pacific
  • Japan
  • China
  • India
  • Australia
  • South Korea
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • Rest of Latin America
• Middle East & Africa
  • South Africa
  • Saudi Arabia
  • Rest of Middle East & Africa