Polyglycerol Sebacate (PGS) Market Size

Polyglycerol Sebacate Market Size

Global Polyglycerol Sebacate Market size was over USD 40 million in 2018 and will grow at a CAGR over 10.6% over the projected period.

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Polyglycerol sebacate is a biocompatible and biodegradable polymer resin formed by polycondensation of sebacic acid (from castor oil) and glycerol. PGS is used as an elastomer in coating of bio textiles such as valves, meshes made up of polyethylene, polyester among others. It is most widely used in tissue engineering especially for nerve and cardiovascular tissue regeneration application. It can also be extruded with some additives which can be used as a bone graft in joint replacement applications. Although the current market of PGS is very negligible and is under development phase, there exists a huge potential to replace other biomaterials such as polylactic acid, poly-L-lactic acid (PLLA), poly glycolic acid (PG), polycaprolactone (PCL) in future as PGS can mimic natural tissue in terms of flexibility. Also, it is soft in nature, robust and has low cost as compared to other biodegradable elastomers. Current applications of PGS elastomer includes nerve guidance, tissue regeneration, blood vessel reconstruction, drug delivery among others. These trends are anticipated to make noteworthy contribution to the overall PGS market size during the forecast timeframe.
 

PGS elastomer finds application as tissue adhesives which can replace the conventional wound closure techniques such as sutures and staples. Also, these adhesives have many advantages such as they are not required to be removed once applied and are bioresorbable in nature, they are less painful and have simple implementation. PGS can be blended with different bioresorbable polymers such as polylactic acid, polycaprolactone in different ratios to obtain scaffolds which have high ductility and high cross link density along with better stretch ability. The market of PGS for adhesives application was estimated over 2.3 tons in 2018 and is estimated to reach 4.56 tons by 2025 growing at a CAGR above 10% annually. PGS elastomer can also be modified for better mechanical strength with addition of materials such as cellulose, carbon nanotubes and silicone-based fillers. With addition of these materials, the tensile strength of PGS can be modified which is further used in extruded products.
 

PGS also finds wide application in biomedical application especially cardiology and ophthalmology. PGS membranes are increasingly being used in retinal transplantation to isolate photoreceptor layers in vivo. PGS is also widely used in tissue engineering especially in cardiac applications. The market of 3D printed scaffolds generated from PGS resin and elastomer are expected to rise in bone tissue regeneration application, which will have positive influence on the PGS market size in the coming years.
 

Innovative product designs and advancements in robotics, rise in 3D printing devices, smart implants, nanotechnology, biologics and tissue engineering will contribute to the PGS market growth in the coming years.
 

Overall, the demand of biomaterials is estimated to grow at a health rate taking in to considertation rise in population growth globally, improvements in healthcare facilities in developing countries, rise in medical tourism facilities, innovative technologies and design, and rising spending power on healthcare facilities globally. Developing countries such as China, India, Malaysia and Thailand will be potential markets for biomaterials in next 5 years as the rate of implants in these countries is less. In Europe, countries such as France and the U.K. offer healthy potential as they are less penetrated.