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Protein Labeling Market - By Product Type (Kits & Reagents), Labeling Method (In-vitro {Enzymatic labeling} In-vivo), Application (Fluorescence Microscopy), End-user (Pharmaceutical and Biotechnology Companies) & Global Forecast 2023 - 2032

  • Report ID: GMI6494
  • Published Date: Aug 2023
  • Report Format: PDF

Protein Labeling Industry Analysis

Protein Labeling Market size accounted for USD 2.2 billion in 2022 and is estimated to grow at 10.6% to reach USD 6.1 billion by 2032. Increasing advancement in molecular biology along with rising biopharmaceutical research, drug development, and diagnostics is expected to boost the market progress.

Protein Labeling Market

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Researchers are embracing innovative labeling methods, including site-specific and bioorthogonal labeling that offers high precision and customization that enables to attain desired outcomes, thereby driving the market expansion. Also, protein labeling aids in characterizing proteins associated with specific diseases, enabling the development of targeted treatments tailored to patient’s unique molecular profiles. Thus, growing shift towards personalized therapies and demand for accurate and efficient protein labeling methods is expected to significantly proliferate the market demand.

Protein labeling refers to the process of attaching specific markers or tags to proteins in order to facilitate their detection, visualization, tracking, or manipulation in various experimental contexts. These labels include fluorescent dyes, radioactive isotopes, enzymes and other molecules that enable researchers to study the behaviour, interactions, and functions of proteins within cells, tissues and biological samples. Protein labeling plays a crucial role in molecular biology, biochemistry, biotechnology, and medical research, allowing scientists to gain insights into protein localization, structural changes, protein-protein interactions, and other important cellular processes.

COVID-19 Impact

The outbreak of COVID-19 pandemic had a slight negative impact on the protein labeling market as the pandemic was noted to have disruption in supply chains and logistics such as obtaining essential reagents and labeling materials, thereby hampered the research and development timelines. Also, laboratory closures and restricted access to research facilities have limited experimentation and validation processes, led to hindering the progress of ongoing projects and stifling innovation in protein labeling techniques. Moreover, reduced research funding, shifting priorities, and uncertainty in economic conditions have compelled some companies and research institutions to scale back or defer their investments in protein labeling technologies.

Protein Labeling Market Trends

The increasing investment in research and development dedicated to proteomics research has significantly amplified the demand for protein labeling solutions. It enables to study the complexities of protein activities, relationships, and expression patterns. With an intensified focus on unravelling the complexities of proteomics, the precision and versatility offered by protein labeling methods have become indispensable tools. This heightened investment has catalysed the advancement of labeling technologies, leading to innovations such as site-specific and bioorthogonal labeling, that enhance accuracy and customization.

Also, the symbiotic relationship between increased R&D expenditure in proteomics research and the sophistication of protein labeling techniques has propelled the field in terms of expediting discoveries and applications across disease diagnostics, drug development, and personalized medicine, thereby fostering the market trends.

Protein Labeling Market Restraint

Lack of skilled professional may significantly hamper the growth trajectory of market. The demand for advanced protein analysis techniques is witnessing significant growth across research, diagnostics, and biopharmaceutical industries. However, shortage of skilled professionals in protein labeling methods have becomes a critical constraint. Skilled professionals play a pivotal role in ensuring the accurate execution of complex labeling procedures, maintaining data integrity, and extracting meaningful insights from experimental results. Thus, owing to which several research studies and projects are witnessing significant delays, impeding scientific advancement and hindering the development of innovative applications.

Protein Labeling Product Type Segmentation

Protein Labeling Market Size, By Product Type, 2021 - 2032 (USD Billion)

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By product type, the protein labeling market is classified into kits & reagents and services. The kits & reagents accounted for 69.3% of the business share in 2022 and is projected to witness robust growth over the analysis timeframe. Protein labeling kits and reagents offer a streamlined solution for researchers, providing ready-to-use tools to attach markers to proteins. This efficiency saves time, ensures accuracy, and reduces potential errors, benefiting both laboratories and those new to protein labeling. Also, with optimized protocols and simplified workflows, these kits enhance reproducibility and lower the risk of experimental variations. Thus, by labeling processes, protein labeling kits and reagents enable researchers to focus on data analysis and scientific insights, thereby contributing to advancements in research, diagnostics, and therapeutic development.

Protein Labeling Method Segmentation

Protein Labeling Market Revenue Share, By Labeling Method, (2022)

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Based on labeling method, the protein labeling market is segmented into in-vitro and in-vivo. The in-vitro labeling method segment is expected to register USD 4.4 billion by 2032. In-vitro protein labeling approach involves labeling proteins outside of living organisms, enabling precise control over conditions and reactions. Also, in-vitro labeling ensures consistent and reproducible results, reducing experimental variability. It allows for customization by selecting specific labeling tags and reagents according to research needs. Moreover, this method minimizes potential interference with cellular processes, maintaining protein functionality and enhances research efficiency, thereby accelerating the segment expansion.

Protein Labeling Application Segmentation

By application, the protein labeling market is segmented into cell-based assays, fluorescence microscopy, immunological techniques, mass spectrometry and protein microarray. The immunological techniques segment accounted for significant market revenue in 2022 and is expected to grow at 9.6% during the forecast period. Protein labeling through immunological approach involves attaching labels to proteins using antibodies, enabling highly specific and targeted labeling. Also, it enables in detecting and quantifying proteins in complex biological samples, enhancing disease diagnostics and biomarker discovery. Furthermore, it offers precision and allows researchers to study protein expression, interactions, and localization with exceptional accuracy.

Protein Labeling End-user Segmentation

The end-user in protein labeling market is categorized into hospitals and clinics, diagnostic laboratories, pharmaceutical and biotechnology companies and other end-users. The pharmaceutical and biotechnology ccompanies segment accounted for USD 992.8 million market revenue in 2022 and is estimated to grow at significant pace during the forecast period. Increasing segmental growth is owing to precise analysis of interactions, functions, and mechanisms of action offered by protein labeling enables pharmaceutical and biotechnology companies to accelerate their R&D process.

Growing focus on targeted therapies and precision medicine is significantly propelling the adoption of protein labeling the pharmaceutical and biotechnology companies. Thus, by leveraging protein labeling capabilities, companies can streamline R&D efforts, improve decision-making, and ultimately accelerate the commercialization of innovative therapies into market, thereby driving the segmental growth.

Protein Labeling Regional Analysis

U.S. Protein Labeling Market Size, 2020 – 2032 (USD Million)

North America protein labeling market accounted for 42.8% business share in 2022 and is anticipated to grow at considerable growth rate during the forecast timeframe. Increasing R&D investments for drug discovery, personalized medicine, and disease diagnostics in the region is expected to significantly proliferate the market growth. Also, presence of key market players especially in U.S. contributes to the growth of market. Further, growing demand for effective disease diagnosis & treatment, favorable government regulations and developed R&D infrastructure further support the expansion of protein labeling, thereby contributing to the market progress in the North America region.

Protein Labeling Industry Leaders

Major market players operating in the protein labeling market include Thermo Fisher Scientific Inc., Merck & Co., Inc, F. Hoffmann-La Roche, Promega Corporation, Bio-Rad Laboratories among others. These industry players majorly adopt various strategies including collaborations, acquisitions, mergers, and partnerships to create a global footprint and sustain market competition.

Protein Labeling Industry News:

  • In January 2023, SCIEX, a global leader in life science analytical technologies, launched Fast Glycan Labeling and Analysis kit for quantitative glycan analysis. This strategy helped the company to enhance its product offerings and drive revenue growth.
  • In January 2020, Abcam plc, a global leader in the supply of life science research tools acquired Expedeon’s Proteomics. This acquisition was aimed to accelerates Abcam's antibody conjugation and labeling business growth. This strategy helped the company to enhance its business growth and consolidate its market position.

The protein labeling market research report includes an in-depth coverage of the industry with estimates & forecast in terms of revenue in USD from 2018 to 2032, for the following segments:

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By Product Type

  • Kits & reagents
  • Services

By Labeling Method

  • In-vitro
    • Dye-based labeling
    • Enzymatic labeling
    • Nanoparticle labeling
    • Site-specific labeling
  • In-vivo
    • Photoreactive labeling
    • Bioorthogonal labeling


  • Cell-based assays
  • Fluorescence microscopy
  • Immunological techniques
  • Mass spectrometry
  • Protein microarray


  • Hospitals and clinics
  • Diagnostic laboratories
  • Pharmaceutical and biotechnology companies
  • Other end-users

The above information is provided for the following regions and countries:

  • North America
    • U.S.
    • Canada
  • Europe
    • Germany
    • UK
    • France
    • Spain
    • Italy
    • Rest of Europe
  • Asia Pacific
    • Japan
    • China
    • India
    • Australia
    • Rest of Asia Pacific
  • Latin America
    • Brazil
    • Mexico
    • Rest of Latin America
  • Middle East & Africa
    • South Africa
    • Saudi Arabia
    • Rest of MEA


Authors: Mariam Faizullabhoy, Gauri Wani

Frequently Asked Questions (FAQ) :

Protein labeling industry was worth USD 2.2 billion in 2022 and is estimated to expand at 10.6% CAGR from 2023-2032 driven by the increasing advancements in molecular biology along with rising biopharmaceutical research, drug development, and diagnostics.

The kits & reagents segment accounted for 69.3% of the market share in 2022 and is projected to expand substantially through 2032 owing to their rising need for streamlined solution for researchers.

North America held 42.8% share of the protein labeling market in 2022 and is anticipated to grow at considerable CAGR through 2032 driven by the increasing R&D investments for drug discovery, personalized medicine, and disease diagnostics in the region.

Some of the top firms operating in the market are Thermo Fisher Scientific Inc., Merck & Co., Inc, F. Hoffmann-La Roche, Promega Corporation, Bio-Rad Laboratories among others.

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  • Base Year: 2022
  • Companies covered: 10
  • Tables & Figures: 369
  • Countries covered: 19
  • Pages: 220
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