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In-situ Hybridization Market Size, COVID-19 Impact Analysis, Regional Outlook, Application Potential, Price Trends, Competitive Market Share & Forecast, 2022 – 2028

  • Report ID: GMI3991

In-Situ Hybridization Market Size is slated to grow commendably from 2022 to 2028, given the rising acceptance of the FISH (fluorescence in-situ hybridization) technique to visualize the spatial locations of DNA and RNA molecules in a sequence-specific manner. The increasing application scope of this technique in cancer care, owing to its ability to target specific areas of chromosomes and their structural makeup within the cancer cell, will further amplify industry demand in the coming years. In-situ hybridization refers to a laboratory technique in which a probe, a single-stranded RNA or DNA, is allowed to develop complementary base pairs with RNA or DNA present in the tissue or chromosome sample. The technique involves the hybridization of a labeled nucleic acid to the suitable prepared tissues or cells on microscope slides to enable visualization in situ.

Strong demand for diagnostic techniques for infectious diseases and the high burden of cancer are some of the key factors bolstering the market trends through 2028. In the U.S., the number of people diagnosed with cancer has been constantly increasing, which could boost in-situ hybridization applications in cancer treatment, as the identification of chromosomal changes in cells can help doctors classify the cancer type and discover effective drugs. Additionally, the growing prevalence of acute bronchitis in the adult population will further fuel the market growth, due to the capability of the FISH protocol to detect infectious viruses.

Considering technique, the Cas9-mediated fluorescence in-situ hybridization segment will hold an appreciable share in the industry by 2028. The segment expansion is on account of the rising popularity of the CRISPR-Cas9 tool among researchers attributed to its ability to correct genetic disorders. Furthermore, the use of this system to modify DNA with high precision, along with its relative versatility and simplicity as compared to existing technologies such as TALEN, will also propel the overall industry share in the coming years.

Europe in-situ hybridization market is set to exhibit a strong growth rate through 2028, driven by the growing incidence of genetic disorders such as congenital adrenal hyperplasia among children in Britain. As the in-situ hybridization technique is used to visualize genetic materials to identify chromosomal abnormalities and genetic mutations, the increased risks of genetic disorders could amplify the industry outlook in the region. Likewise, the significant launch of diagnostic centers will further augment the regional growth during the forecast timeframe.

Key players in the industry include Abnova Corporation, Bio SB, Advanced Cell Diagnostics, Inc. (Bio-Techne), Exiqon (Qiagen), Agilent Technologies, F. Hoffmann-La Roche AG, Abbott, Creative-Biolabs, Accelerate Diagnostics, Inc., Biocare Medical, Genemed Biotechnologies, BioGenex, Thermo Fisher Scientific, and PerkinElmer. These market leaders are focusing on strategies like new product launches to reinforce their presence in the competitive industry.

For instance, in March 2021, Roche unveiled the DISCOVERY Green HRP kit, developed to expand the multiplexing capability of IHC (immunohistochemistry) and ISH (in-situ hybridization) through the delivery of distinct colors in contrast with other chromogens. In January 2021, BioCare Medical, LLC released ONCORE Pro, its fully automated staining platform, for ISH and IHC applications.

Impact of COVID-19 on In-situ Hybridization Market Trends:

Healthcare sectors worldwide have witnessed massive disruptions caused by the novel coronavirus outbreak. During the peak of the pandemic, a substantial decline in precancer and cancer diagnosis was witnessed, particularly due to the drop in the number of screening tests performed. These factors may have hindered the use of in-situ hybridization as a molecular tool for cancer diagnosis in recent months. However, the significant development of FISH probes to visualize SARS-CoV-2 RNA in the infected cells may assert a positive influence on the industry over the coming years.

The market research report of in-situ hybridization includes in-depth coverage of the industry with estimates & forecast in terms of revenue in USD from 2017 to 2028 for the following segments:

Market, by Probe Type

  • DNA
    • Double-stranded DNA (dsDNA) probes
    • Single-stranded DNA (ssDNA) probes
  • RNA
  • Synthetic oligonucleotides (PNA, LNA)

Market, by Technique

  • Chromogenic in-situ hybridization
  • Fluorescence in-situ hybridization
  • Cas9-mediated fluorescence in-situ hybridization

Market, by Application

  • Microbiology
  • Pathology
  • Cancer diagnosis
  • Karyotyping and phylogenetic analysis
  • Physical mapping
  • Developmental biology

Market, by End-use

  • Research & diagnostic laboratories
  • Academic institutes
  • Pharmaceutical and biotechnology companies
  • Contract research organizations (CROs)
  • Others

The above information is provided for the following regions and countries:

  • North America
    • U.S.
    • Canada
  • Europe
    • Germany
    • UK
    • France
    • Italy
    • Spain
    • Russia
    • Poland
  • Asia Pacific
    • Japan
    • China
    • India
    • Australia
  • Latin America
    • Mexico
    • Brazil
    • Argentina
  • Middle East and Africa
    • South Africa
    • Saudi Arabia
    • Kuwait
    • UAE


What Information does this report contain?

Historical data coverage: 2017 to 2021; Growth Projections: 2022 to 2028.
Expert analysis: industry, governing, innovation and technological trends; factors impacting development; drawbacks, SWOT.
6-7 year performance forecasts: major segments covering applications, top products and geographies.
Competitive landscape reporting: market leaders and important players, competencies and capacities of these companies in terms of production as well as sustainability and prospects.

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