U.S Peptide Therapeutics Market was valued to be around USD 17.8 billion in 2022 and is projected to witness massive growth at a CAGR of around 7% from 2023 to 2032. The factors driving the market growth are increasing prevalence of chronic disorders, rising healthcare expenditure, technological advancements, and growing disposable income in the country.
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Moreover, rising incidences of metabolic disorders, cancer, cardiovascular disorders, gastrointestinal disorders, and central nervous system disorders are increasing the demand for effective peptide therapeutics for such conditions.
Peptides consist of short chains of amino acids connected by peptide bonds. Peptide therapeutics serve as crucial replacement therapies that supplement peptide hormones when there are insufficient endogenous levels. Peptides bind to specific surface receptors and their ligands on cells, thus aiding in the treatment of diseases by influencing the cell membrane.
|U.S. Peptide Therapeutics Market Size in 2022:||USD 17.8 Billion|
|Forecast Period:||2023 to 2032|
|Forecast Period 2023 to 2032 CAGR:||7%|
|2032 Value Projection:||USD 35.7 Billion|
|Historical Data for:||2018 to 2022|
|No. of Pages:||140|
|Tables, Charts & Figures:||82|
|Segments covered:||Type, Application, Route of administration, Manufacturer type, Synthesis technology, Distribution channel|
|Pitfalls & Challenges:|
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The U.S. peptide therapeutics market saw moderate COVID-19 impact. Key players developed peptide-based COVID-19 treatments, leading to clinical trials for numerous vaccines. Supply chain disruptions caused shortages in peptide drug manufacturing. Pharmaceutical firms redirected resources to COVID-19 research, affecting peptide studies in universities and businesses. The pandemic accelerated telemedicine adoption, revealing supply chain vulnerabilities. Antiviral peptide demand rose for COVID-19 and future outbreaks. As COVID-19 cases declined, surgical care resumption and increased procedural volumes aided peptide therapeutics recovery, signalling market growth despite initial challenges.
The increasing incidence of metabolic disorders plays a significant role in driving the market share. Metabolic disorders encompass a wide range of conditions that affect the body's metabolism, including diabetes, obesity, and rare genetic disorders. Type 2 diabetes is a highly prevalent metabolic disease worldwide, often attributed to sedentary lifestyles, poor dietary habits, and genetic factors. Peptide-based medications, such as GLP-1 receptor agonists, have become increasingly important in managing blood glucose levels in diabetes. According to the CDC's National Diabetes Statistics Report for 2022, diabetes affects 37.3 million individuals, or 11.3% of the U.S. population, with an estimated 28.7 million diagnosed
Overall, the demand for innovative and personalized treatments for metabolic disorders is fostering research and development efforts, ultimately leading to the creation of novel peptide-based therapies to address the unmet medical needs of patients with metabolic disorders.
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Based on type, the U.S. peptide therapeutic market is subdivided into branded and generic peptide. The branded peptide segment accounted for majority revenue share in 2022 and is expected to reach USD 22.83 billion by 2032. The largest share of this segment can be attributed to several factors, including the higher number of prescriptions for branded drugs, the perceived quality and efficacy of branded peptide therapeutics compared to generics, patient preferences for branded products, and insurance coverage.
Additionally, the market growth is driven by the efforts of pharmaceutical players to launch new drugs. Some of the prominent players in the peptide therapeutics market are focusing on expanding the application areas for their existing peptide therapeutics.
Based on applications, the U.S. peptide therapeutics market is classified into metabolic & endocrine disorders, cancer, cardiovascular disorders, gastrointestinal disorders, central nervous system disorders, respiratory disorders, pain management, renal disorders, dermatology, and other applications. The metabolic and endocrine disorders segment accounted for the largest share in 2022. Metabolic disorders, such as diabetes, obesity, and lipid metabolism disorders, pose a significant disease burden. The market's growth is primarily driven by the escalating prevalence of these conditions. In the U.S., the obesity epidemic has intensified efforts to develop effective treatments for obesity-related metabolic disorders. Peptide therapeutics that target appetite control and weight management are being developed to tackle this mounting health challenge.
Based on route of administration the U.S. peptide therapeutics market is subdivided parenteral, oral, and other routes of administration. Among the route of administrations segment, parenteral segment held highest revenue share of market in 2022. This attributes to the factors like fast drug delivery, high adoption rate, and ease of administration. A noteworthy trend in subcutaneous injections is the development of self-administration devices designed for user-friendliness. Examples of these devices are autoinjectors and pen injectors, which make it more convenient for patients to self-administer peptide therapies at home, thereby enhancing treatment adherence and convenience.
Additionally, the parenteral method allows for the administration of multiple peptides or peptide-based medicines in a single injection. This capability is particularly crucial in the treatment of complex diseases like diabetes and cancer, where multiple therapeutic targets can be addressed simultaneously. Moreover, parenteral delivery is being explored using minimally invasive injectable technologies such as microneedle arrays, which offer reduced pain and increased patient acceptability.
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Based on manufacturer type, the U.S. peptide therapeutics market is classified into in-house and outsourced. The in-house segment dominated the market with the highest market share of around 64.4% in 2022. Key players in the industry are increasingly focusing on developing peptide therapeutics in-house due to the high costs associated with outsourcing and stringent regulatory requirements. Moreover, these companies are making substantial investments in establishing Good Manufacturing Practice (GMP)-compliant peptide production facilities. These facilities are designed to adhere to rigorous quality and safety standards, ensuring the production of safe and effective peptide therapies.
Furthermore, many companies are expanding their in-house manufacturing capabilities to meet the rising demand for peptide-based therapies. This expansion includes the incorporation of new production lines, equipment, and the hiring of additional personnel. Additionally, as peptides progress through the preclinical and clinical development stages, in-house facilities offer the ability to scale up manufacturing. This scalability ensures a seamless transition from research to commercial production.
Based on synthesis technology, the U.S. peptide therapeutics market is subdivided into liquid-phase peptide synthesis, solid-phase peptide synthesis, and hybrid technology. The liquid-phase peptide synthesis segment held the majority of market share in 2022. Automation has significantly enhanced the efficiency, precision, and repeatability of Liquid Phase Peptide Synthesis (LPPS). Automated peptide synthesizers are becoming increasingly sophisticated, enabling high-throughput peptide production for research, development, and commercial manufacturing. Additionally, the downsizing of LPPS processes reduces the consumption of reagents and solvents, rendering the process more environmentally friendly and cost-efficient.
Based on distribution channel, the U.S. peptide therapeutics market is segmented into hospital, retail, and online pharmacies. The hospital pharmacies segment dominated the U.S. peptide market in 2022. Hospital pharmacies typically maintain a well-stocked inventory of essential medications, including peptide drugs. This immediate availability is critical in a hospital setting where timely administration of medications is often vital for patient care. Hospital pharmacies collaborate closely with physicians, including specialized care teams, to optimize the use of peptide treatment options and give information on dose, administration, and monitoring.
Also, certain hospital pharmacists are prepared to create specialized peptide formulations, such as modified doses or specific peptide combinations, to address the needs of individual patients. However, these above trends reflect the evolving significance of hospital pharmacies in the peptide therapeutics industry, with a focus on optimizing patient care, improving treatment results, and assuring the safe and efficient administration of peptide-based treatments in a hospital setting.
The key players in peptide therapeutics market are
These companies are implementing several strategies such as collaborations, acquisitions, partnerships, mergers, and product launches, etc. to maintain a competitive edge in the industry.
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By Route of Administration
By Manufacturer Type
By Synthesis Technology
By Distribution Channel