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Premium Report Details
Base Year: 2024
Companies covered: 12
Tables & Figures: 116
Countries covered: 19
Pages: 130
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Primary Immunodeficiency Disorders Market
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Primary Immunodeficiency Disorders Market Size
The global primary immunodeficiency disorders market was valued at USD 7.8 billion in 2024. The market is expected to grow from USD 8.2 billion in 2025 to USD 13.9 billion in 2034, at a CAGR of 6.1% during the forecast period. The market is driven by the rising cases of primary immunodeficiency globally, coupled with increasing awareness among healthcare professionals and patients.
For instance, as per the report published by the National Institute of Health, it is estimated that around 6 million people worldwide are affected by primary immunodeficiencies (PIDs), though the vast majority (70-90%) remain undiagnosed in 2021. Over 400 different PIDs have been identified, each resulting from inherited defects in the immune system.
Advancement in diagnostics and treatment such as the introduction of innovative gene therapy and biologics are expanding the available treatment options and improving patient outcomes, thereby contributing to market growth. Also, the increasing research funding for the development of novel treatment options is fueling market growth and offering enhanced management strategies for these complex disorders.
The market is further strengthened by increasing training in immunology which leads to earlier and more accurate diagnoses. Supportive networks and advocacy groups are helping patients access care and pushing for policy improvements, thereby contributing to market growth. The widespread availability of advanced diagnostic tools such as flow cytometry and genetic panels is increasing detection rates of primary immunodeficiency. Urbanization, better healthcare access, and growing disposable income, especially in emerging economies such as India, China, Brazil, and South Africa also contribute to increase in diagnostic rates, thereby driving the market growth.
Primary immunodeficiency disorders (PIDs) are a group of inherited conditions where the immune system doesn't work properly, making individuals more susceptible to infections and other health problems. These disorders are typically genetic, that means they are passed down from parents to children. The market includes various disease types, with product development focusing on rapid symptom relief, preventing recurrence, and improving patient’s health.
Primary Immunodeficiency Disorders Market Trends
Primary Immunodeficiency Disorders Market Analysis
In 2021, the global market was valued at USD 6.7 billion. The following year, it saw a slight increase to USD 7 billion, and by 2023, the market further climbed to USD 7.4 billion.
Based on disease type, the global market is divided into antibody deficiencies, combined immunodeficiencies, complement deficiencies, phagocytic disorders and other disease types. The antibody deficiencies segment dominated the market in 2024 and was valued at USD 4.1 billion.
Based on the treatment type, the global primary immunodeficiency disorders market is categorized into immunoglobulin replacement therapy (IRT), hematopoietic stem cell transplantation (HSCT), gene therapy and other treatment types. In 2024, the immunoglobulin replacement therapy (IRT) segment accounted for the largest share of 68.3% in the global market.
Based on the age group, the global primary immunodeficiency disorders market is categorized into pediatric and adult. The pediatric segment held the highest market revenue USD 5.1 billion in 2024.
Based on end use, the primary immunodeficiency disorders market is categorized into hospitals, specialty clinics, homecare settings and other end users. The hospitals segment is expected to reach USD 6.7 billion by 2034.
The North America primary immunodeficiency disorders market dominated the global market with a market share of 41.8% in 2024.
The U.S. market was valued at USD 2.5 billion and USD 2.6 billion in 2021 and 2022, respectively. The market size reached USD 2.9 billion in 2024, growing from USD 2.8 billion in 2023.
Europe primary immunodeficiency disorders market accounted for USD 2 billion in 2024 and is anticipated to show lucrative growth over the forecast period.
Germany dominates the European primary immunodeficiency disorders market, showcasing strong growth potential.
The Asia Pacific primary immunodeficiency disorders market is anticipated to grow at the highest CAGR of 6.4% during the analysis timeframe.
China primary immunodeficiency disorders market is estimated to grow with a significant CAGR in the Asia Pacific market.
Brazil leads the Latin American primary immunodeficiency disorders market, exhibiting considerable growth during the analysis period.
Saudi Arabia primary immunodeficiency disorders market to experience substantial growth in the Middle East and Africa market.
Primary Immunodeficiency Disorders Market Share
In 2024, the market remains consolidated, with top key players accounting for approximately 50–55% of the global market share. The top 5 players such as Baxter International, CSL Behring, Takeda Pharmaceutical, ADMA Biologics, and F. Hoffmann La Roche account for a significant share of the global market. Leading pharmaceutical and healthcare companies are leveraging a multi-pronged strategic approach including acquisitions, partnerships, R&D investments, and innovative product launches to reinforce their competitive positioning and respond to the rising prevalence of primary immunodeficiency disorders globally. Companies are actively adopting multi-pronged approaches to address the rising demand for novel drug therapeutics to treat primary immunodeficiency disorders.
Primary Immunodeficiency Disorders Market Companies
The company profile section includes both companies that have commercial drug available in the market as well as those that are onto clinical phase development. Prominent players operating in the market are as mentioned below:
Many leading players focus on product approval, advancements and collaboration to gain a competitive edge in the market. For instance, X4 Pharmaceuticals recently announced FDA approval of XOLREMDI (mavorixafor) for WHIM syndrome, a rare PID.
Grifols' Biotest received FDA approval for Yimmugo, an immunoglobulin for primary immunodeficiencies.
These launches typically include details about the drug's mechanism, target patient population, and clinical trial data supporting its efficacy and safety, along with information about the company and its commitment to addressing rare diseases.
Primary Immunodeficiency Disorders Industry News:
The primary immunodeficiency disorders market research report includes in-depth coverage of the industry with estimates and forecast in terms of revenue in USD Million from 2021 – 2034 for the following segments:
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Market, By Disease Type
Market, By Treatment Type
Market, By Age Group
Market, By End Use
The above information is provided for the following regions and countries: