Nucleic Acid Isolation Purification Market

Nucleic Acid Isolation & Purification Market Size

Nucleic Acid Isolation & Purification Market size was valued USD 5 billion in 2023 is poised to record more than 7.7% CAGR from 2024 to 2032. The market growth is driven by the escalating demand for advanced diagnostic techniques, particularly in genomics and precision medicine, that fuels the need for efficient nucleic acid isolation and purification methods.

Moreover, continuous advancements in technology, such as automated nucleic acid isolation systems and high-throughput methods, enhance the efficiency and scalability of nucleic acid purification processes. For instance, in 2021, Thermo Fisher Scientific launched kingfisher apex purification system, a high-throughput sample purification instrument to automate the extraction of DNA, RNA, proteins and cells from an array of sample types. This instrument can process 24 to 96 samples in 25 to 65 minutes. Such advancements and introduction of new products is expected to fuel the market progress.

Nucleic acid isolation & purification refer to the processes of extracting and refining nucleic acids, such as DNA or RNA from biological samples, such as cells or tissues. These processes are crucial in molecular biology, genetics, and other fields where the analysis of nucleic acids is essential.

COVID-19 Impact

The COVID-19 pandemic positively impacted the nucleic acid isolation & purification market by fostering innovations and heightened demand for molecular diagnostics. The urgent need for efficient and rapid nucleic acid testing for SARS-CoV-2 detection accelerated advancements in isolation and purification technologies. This surge in research and development bolstered the market's growth and led to the creation of robust, automated, and high-throughput systems. Also, these developments helped cater to the immediate pandemic-related requirements and contributed to the broader field of molecular biology and diagnostic applications, positioning the nucleic acid isolation and purification market for sustained growth in the post-pandemic era.

Nucleic Acid Isolation & Purification Market Trends

• The increasing demand for molecular diagnostics has emerged as a key driver propelling the market expansion. As molecular diagnostics plays a pivotal role in understanding and diagnosing various diseases at a genetic level, the need for reliable and efficient nucleic acid isolation and purification methods has surged.
  
• Additionally, as medical treatments increasingly shift towards personalized approaches tailored to individual genetic profiles, the demand for efficient nucleic acid isolation and purification techniques is further rising. For instance, in 2014, personalized medicines accounted for only 21% of the total FDA approved new molecular entities, while in 2022 they accounted for 34% of approved new molecular entities. Therefore, nucleic acid isolation and purification plays a pivotal role in extracting high-quality genetic material, such as DNA and RNA, essential for personalized diagnostics and targeted therapies.
  

However, high cost associated with installation and maintenance of instruments and use of cost-intensive reagents during purification and isolation procedures of nucleic acid are expected to restrain growth of the market to a certain extent over the forecast period.

Nucleic Acid Isolation & Purification Market Analysis

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Based on product, the market is segmented into reagents & kits and instruments. The reagents & kits segment is expected to lead the market, projecting revenue of USD 7.3 billion by 2032.

• The development of innovative reagents and kits with enhanced performance, automation capabilities, and compatibility with high-throughput systems has significantly contributed to the expansion of this segment. For instance, Thermo Fisher’s PrepSEQ 1-2-3 nucleic acid extraction kit rapidly extracts mycoplasma genomic DNA from 100 µL sample volumes. The kit is also optimized for use with the MycoSEQ mycoplasma detection kit.
  
• Similarly, the demand for kits used in the isolation and purification of nucleic acids is on the rise, driven by the increasing number of research studies focused on genome-based diseases.
  

Learn more about the key segments shaping this market

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Based on type, the nucleic acid isolation and purification market is classified into RNA isolation & purification and DNA isolation & purification. The RNA isolation & purification segment is further categorized into mRNA isolation & purification, miRNA isolation & purification, total RNA isolation & purification, and other RNA isolation & purification types. The RNA isolation & purification segment dominated the market accounting for the highest share of 52.6%. in 2023.

• High market share can be attributed to the expanding applications of RNA-based technologies, such as gene expression analysis, RNA sequencing, and emerging therapeutic modalities like RNA interference.
  
• Additionally, advent of RNA-based therapeutics, such as mRNA vaccines and gene therapies highlight the need for robust isolation and purification protocols, thus solidifying the high growth of the segment.
  

Based on method, the nucleic acid isolation & purification market is segmented into magnetic beads, column-based, reagent-based, and other methods. The magnetic beads segment dominated the market in 2023 and is projected to grow at a CAGR of 7.8% over the analysis period.

• The growing adoption of magnetic beads is owing to the advantage that it provides to researchers and scientists with improved assay performance and better isolation and purification of DNA and RNA.
  
• Additionally, its simplicity, speed, and adaptability to various sample types are few of the other key advantages associated with magnetic beads, thereby augmenting the market progression.
  

Based on application, the nucleic acid isolation and purification market is classified into diagnostics, drug discovery & development, precision medicine, and other applications. The diagnostics segment dominated the market accounting for the largest revenue in USD 1.7 billion in 2023.

• The large revenue share of the segment can be attributed to the rising application of DNA and RNA isolation for the identification of pathogens in routine sample processing.
  
• Also, laboratories, research institutions, and healthcare facilities including hospital settings are increasingly relying on advanced diagnostics based on nucleic acid analysis, driving the market's expansion.
  

Based on end-use, the nucleic acid isolation & purification market is classified into hospitals and diagnostic centers, pharmaceutical & biotechnology companies, contract research organizations, and other end-users. The hospitals and diagnostic centers segment dominated the market in 2023.

• Hospitals and diagnostic centers, being the frontline providers of healthcare services, invest heavily in cutting-edge technologies and equipment for nucleic acid isolation and purification. These setting serve as the primary facilities for patients undergoing major diagnostic tests, making them the focal point, thereby contribute significantly to their substantial market share.
  

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 In 2023, North America held a significant business share of 37.8% in the nucleic acid isolation and purification market and is anticipated to dominate the market throughout the forecast period.

• The presence of leading biotechnology and pharmaceutical companies, coupled with significant government investments in genomics and molecular biology research, has propelled North America to the forefront of nucleic acid isolation and purification.
  
• Moreover, a high level of awareness among healthcare professionals and researchers, coupled with an increasing demand for personalized medicine and diagnostics, further accentuates the region's dominance in the market.
  

Nucleic Acid Isolation &s Purification Market Share

The nucleic acid isolation and purification industry is characterized by diverse players competing in the industry, leveraging their research capabilities and global presence. Strategic collaborations, product innovations, and regulatory compliance further strengthen their positions. The market is characterized by ongoing technological advancements and a focus on developing safer and more effective instruments and kits, intensifying the competitive dynamics in the healthcare sector.

Nucleic Acid Isolation &s Purification Market Companies

The prominent players operating in the nucleic acid isolation and purification industry is as mentioned below:

• QIAGEN N.V.
• Thermo Fisher Scientific Inc.
• Illumina Inc.
• Danaher Corporation
• F. Hoffmann La Roche Ltd
• Merck KGaA
• Agilent Technologies Inc.
• Bio-Rad Laboratories
• Takara Bio Inc.
• Promega Corporation
• New England Biolabs
• Abcam plc.
• PCR Biosystems
  

Nucleic Acid Isolation and Purification Industry News:

• In July 2023, INOVIQ Limited, a developer of exosome solutions and precision diagnostics, and Promega Corporation announced a joint marketing agreement to co-market INOVIQ’s EXO-NET exosome capture technology and Promega nucleic acid purification systems. This strategy helped the companies to deliver their exosome tools and technologies to researchers, pharma, and clinical laboratories globally, thereby enhancing their customer base.
  
• In October 2021, Thermo Fisher Scientific launched its MagMAX wastewater ultra nucleic acid isolation kit for SARS-CoV-2 surveillance. This helped the company expand its product offerings.
  

The nucleic acid isolation and purification market research report includes an in-depth coverage of the industry with estimates & forecast in terms of revenue in USD Million from 2018 to 2032 for the following segments:

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By Product, 2018 – 2032 (USD Million)

• Reagents & kits
• Instruments

By Type, 2018 – 2032 (USD Million)

• RNA isolation & purification
• mRNA isolation & purification
• miRNA isolation & purification
• Total RNA isolation & purification
• Other RNA isolation & purification types 
• DNA isolation & purification
• Genomic DNA isolation & purification
• Plasmid DNA isolation & purification
• Viral DNA Isolation & Purification
• Other DNA isolation & purification types

By Method, 2018 – 2032 (USD Million)

• Magnetic beads
• Column-based
• Reagent-based
• Other methods

By Application, 2018 – 2032 (USD Million)

• Diagnostics
• Drug discovery & development
• Precision medicine
• Other applications

By End-use, 2018 – 2032 (USD Million)

• Hospitals and diagnostic centers
• Pharmaceutical & biotechnology companies
• Contract research organizations
• Other end-users

The above information is provided for the following regions and countries:

• North America
  • U.S.
  • Canada 
• Europe
  • Germany
  • UK
  • France
  • Spain
  • Italy
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • Australia
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • Rest of Latin America
• Middle East & Africa
  • South Africa
  • Saudi Arabia
  • Rest of Middle East & Africa